Document Detail

Comparison of plasma biomarkers with dietary assessment methods for fruit and vegetable intake.
MedLine Citation:
PMID:  12879094     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the variability and validity of plasma-based biomarkers of antioxidant vitamin, and fruit and vegetable intake. SETTING: Leeds, Wakefield, Huddersfield and Bradford, England. SUBJECTS: A total of 54 free-living, nonsmoking women recruited from participants of the UK Women's Cohort Study (UKWCS). METHODS: Two fasting blood samples were taken at two time points, 18 months apart. A 4-day food diary was completed prior to the first blood sample and a 24-h recall was conducted at the time of the second blood collection. All blood samples were analysed for ascorbic acid and four carotenoids. Associations between antioxidant vitamin intake from all food sources and supplements, as well as fruit and vegetable intake, and plasma levels of the antioxidant vitamins were assessed. RESULTS: Using the 4-day diary, positive associations were found between micronutrient intake from all food sources and plasma concentrations of ascorbic acid (P<0.01) and beta-carotene (P<0.01). No associations were seen between plasma micronutrient levels and specifically fruit and vegetable intakes. In general, associations between plasma levels and intakes assessed by the 24-h recall were less marked than those based on the 4-day diary. CONCLUSIONS: Plasma ascorbic acid and beta-carotene are good indicators of previous vitamin C and beta-carotene intake, from all food sources. However, caution is required in extrapolating these results to include individual food groups, rich in these vitamins. The results imply that the practice of using plasma biomarkers simply as a proxy measure of dietary intake is not valid and emphasise that plasma biomarkers are not simply a reflection of dietary intake, but also of a number of physiological processes. Biomarkers in nutrition epidemiological studies are however useful to measure nutrient status at the tissue level.
J Pollard; C P Wild; K L M White; D C Greenwood; J E Cade; S F L Kirk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  57     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-24     Completed Date:  2003-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  988-98     Citation Subset:  IM    
Nutrition Epidemiology Group, Nuffield Institute for Health, University of Leeds, Leeds, UK.
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MeSH Terms
Antioxidants / administration & dosage*,  metabolism
Ascorbic Acid / blood*
Biological Markers / blood
Carotenoids / blood*
Cohort Studies
Middle Aged
Nutrition Assessment
Vitamins / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Vitamins; 36-88-4/Carotenoids; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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