Document Detail

Comparison of physiological and pharmacological stimulation of acid secretion in vagally innervated and denervated gastric pouches in the same dog.
MedLine Citation:
PMID:  7233068     Owner:  NLM     Status:  MEDLINE    
The double-pouch dog with one vagally innervated Amdrup pouch (AP) taken from the lesser curvature side of the stomach and one denervated Heidenhain pouch (HP) from the corporo-fundic part permitted comparison of gastric secretion from innervated and denervated mucosa at the same time in the same animal. Food stimulation with a mixture of liver, heart, and bonemeal showed significantly higher response from AP than from HP for all doses, and the difference between the pouches in total acid output was constant for all doses, indicating that the relative contribution of vagal innervation is diminished when the size of the protein meal is increased. The difference between innervated and denervated mucosa is achieved by an immediate high response from the AP. After 150 min the responses to the larger meals were identical in the two pouches. Acid output during stimulation with pentagastrin reached 64.4% of maximal response to histamine in the AP and 36.2% in the HP, the innervated mucosa giving a statistically significant higher response for all doses. Absence of innervation gave an HP response similar to non-competitive inhibition with significantly lower calculated maximal response and a CD50 not different from the CD50 for the AP. Twenty-four hour secretion studies during optimal physiological conditions with the dog fed two daily meals of standard composition showed sparse secretion from denervated mucosa, whereas a great part of the capacity of innervated mucosa is utilized during daily conditions.
I Guldvog; D Gedde-Dahl
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  15     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  929-37     Citation Subset:  IM    
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MeSH Terms
Gastric Acid / secretion*
Histamine / pharmacology
Models, Biological
Pentagastrin / pharmacology
Secretory Rate / drug effects
Stomach / innervation*,  physiology
Vagus Nerve / physiology*
Reg. No./Substance:
51-45-6/Histamine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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