| Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. | |
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MedLine Citation:
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PMID: 10356087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phylloquinone (K) absorption was assessed in 22- to 30-y-old human subjects consuming a standard test meal [402 kcal (1682 kJ), 27% energy from fat]. The absorption of phylloquinone, measured over a 9-h period as the area under the curve (AUC), was higher (P < 0.01) after the consumption of a 500- microgram phylloquinone tablet [27.55 +/- 10.08 nmol/(L. h), n = 8] than after the ingestion of 495 microgram phylloquinone as 150 g of raw spinach [4.79 +/- 1.11 nmol/(L. h), n = 3]. Less phylloquinone (P < 0.05) was absorbed from 50 g of spinach (AUC = 2.49 +/- 1.11 nmol/(L. h) than from 150 g of spinach. Absorption of phylloquinone from fresh spinach (165 microgram K), fresh broccoli (184 microgram K) and fresh romaine lettuce (179 microgram K) did not differ. There was no difference in phylloquinone absorption from fresh or cooked broccoli or from fresh romaine lettuce consumed with a meal containing 30 or 45% energy as fat. |
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Authors:
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A K Garber; N C Binkley; D C Krueger; J W Suttie |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 129 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-06-24 Completed Date: 1999-06-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1201-3 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, Institute on Aging, and Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Biological Availability Brassica Humans Lettuce Spinacia oleracea Tablets Vegetables* Vitamin K 1 / administration & dosage, pharmacokinetics*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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5 PO1 DK14881/DK/NIDDK NIH HHS; 5 T32 DK07665/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tablets; 84-80-0/Vitamin K 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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