Document Detail

Comparison of pharmacokinetics, metabolic effects and mechanisms of action of glyburide and glipizide during long-term treatment.
MedLine Citation:
PMID:  3123184     Owner:  NLM     Status:  MEDLINE    
Fourteen non-insulin-dependent diabetic (NIDDM) patients continued their previous medication (7 on glyburide, 7 on glipizide) for 6 mo, after which they switched to the alternate treatment for another 6 mo. The treatment periods were followed by 1 mo of placebo. The sulfonylurea dose was increased to achieve fasting plasma glucose levels less than 9 mM or to a total maximum daily dose of 25 mg. The mean final doses of glyburide (14.7 +/- 2.4 mg/day) and glipizide (15.2 +/- 2.2 mg/day) were similar. Postprandial (postdose) glipizide levels were higher than those of glyburide, whereas fasting (predose) glyburide concentrations were higher than those of glipizide. Both treatments improved glucose control by 25% compared with placebo. Glipizide therapy evoked higher postprandial insulin concentrations than did glyburide, whereas basal insulin concentrations were higher during glyburide. Insulin sensitivity, assessed by an insulin tolerance test, was more improved with glyburide than with glipizide. In conclusion, overall glucose control is similarly improved by glyburide and glipizide. However, glipizide amplifies the plasma insulin response to meals more than glyburide, whereas glyburide enhances basal insulin secretion more than glipizide. Both pharmacokinetic and pharmacodynamic factors may contribute to these differences.
L Groop; P H Groop; S Stenman; C Saloranta; K J Tötterman; F Fyhrquist; A Melander
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  10     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:    1987 Nov-Dec
Date Detail:
Created Date:  1988-03-16     Completed Date:  1988-03-16     Revised Date:  2010-08-11    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
Fourth Department of Medicine, Helsinki University Hospital, Finland.
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MeSH Terms
Blood Glucose / metabolism
C-Peptide / blood
Clinical Trials as Topic
Diabetes Mellitus, Type 2 / blood,  drug therapy*,  urine
Glipizide / pharmacokinetics*,  pharmacology,  therapeutic use
Glyburide / pharmacokinetics*,  pharmacology,  therapeutic use
Hemoglobin A, Glycosylated / analysis
Insulin / blood
Lipids / blood
Middle Aged
Sulfonylurea Compounds / pharmacokinetics*
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Hemoglobin A, Glycosylated; 0/Lipids; 0/Sulfonylurea Compounds; 10238-21-8/Glyburide; 11061-68-0/Insulin; 29094-61-9/Glipizide

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