Document Detail


Comparison of the pharmacokinetics of glipizide and glibenclamide in man.
MedLine Citation:
PMID:  823030     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four subjects received 5 mg 14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg 14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-lives increased steadily with time. The two sulfonylureas were extensively metabolized and were excreted in the urine as hydroxylated or conjugated metabolites. The effects of both drugs on blood glucose and immunoreactive insulin were comparable. The findings are compared with other published results.
Authors:
L Balant; J Fabre; G R Zahnd
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  8     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Blood Glucose
Female
Glipizide / administration & dosage,  metabolism*
Glyburide / administration & dosage,  metabolism*
Half-Life
Humans
Injections, Intravenous
Insulin / blood
Intestinal Absorption
Kinetics
Male
Sulfonylurea Compounds / metabolism*
Tablets
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Sulfonylurea Compounds; 0/Tablets; 10238-21-8/Glyburide; 11061-68-0/Insulin; 29094-61-9/Glipizide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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