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Comparison of perinatal outcome after pre-viable preterm prelabour rupture of membranes in two centres with different rates of termination of pregnancy.
MedLine Citation:
PMID:  22260429     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Azria E, Anselem O, Schmitz T, Tsatsaris V, Senat M, Goffinet F. Comparison of perinatal outcome after pre-viable preterm prelabour rupture of membranes in two centres with different rates of termination of pregnancy. BJOG 2012; DOI: 10.1111/j.1471-0528.2011.03265.x. Objective  To assess perinatal outcomes after expectant management in the case of preterm prelabour rupture of membranes (PPROM) before 25 weeks of gestation, according to the rate of termination of pregnancy (TOP). Design  Retrospective comparative cohort study. Population  Singleton pregnancies complicated by PPROM between 15(0/7) and 24(6/7)  weeks of gestation, from January 2003 to January 2007. Methods  Comparison of perinatal outcomes in two French tertiary care referral centres presumed to have different rates of TOP. Main outcome measure  Rates of TOP, survival and survival without major morbidity. Results  A total of 113 women experienced PPROM (49 in centre A and 64 in centre B). A lower proportion of patients opted for TOP in centre A (40.8%) than in centre B (56.3%). The baseline characteristics of patients and pregnancies, and gestational age at PPROM, were not different between the two centres. Mean gestational age at delivery (28.1 versus 25.4 weeks of gestation; P < 0.01), mean latency period (45.5 versus 16.1 days; P < 0.01), mean birthweight (1295 versus 929 g; P = 0.04) and survival (46.9 versus 20.3%; P < 0.01) were significantly higher in centre A than in centre B. The percentage of neonates alive without major morbidity was also higher in centre A than in centre B (42.9 versus 20.3%; P = 0.01). Conclusions  Perinatal outcomes of pregnancies managed expectantly were not better in the centre where the TOP rate was higher. The perinatal risk of pregnancies complicated by pre-viable PPROM remains high.
Authors:
E Azria; O Anselem; T Schmitz; V Tsatsaris; Mv Senat; F Goffinet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-20
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
Affiliation:
Department of Obstetrics and Gynaecology, Groupe Hospitalier Bichat Claude Bernard, APHP, Paris, France Université Paris 7 Diderot, Paris, France Department of Obstetrics and Gynaecology, Groupe Hospitalier Cochin Port Royal Saint Vincent de Paul, APHP, Paris, France Université Paris 5 Descartes, Paris, France Department of Obstetrics and Gynaecology, Hôpital Robert Debré, APHP, Paris, France Department of Obstetrics and Gynaecology, Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France Department of Obstetrics and Gynaecology, Hôpital Antoine Béclère, APHP, Clamart, France.
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