| Comparison of perfusion MRI by flow-sensitive alternating inversion recovery and dynamic susceptibility contrast in rats with permanent middle cerebral artery occlusion. | |
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MedLine Citation:
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PMID: 16075409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared cerebral blood flow (CBF) parameters obtained by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with those obtained by flow-sensitive alternating inversion recovery (FAIR) in brain regions with different perfusion levels in rats with permanent middle cerebral artery (MCA) occlusion. MCA occlusion was performed in 19 rats. T2-weighted MRI, FAIR and DSC-MRI were performed within 48 h after occlusion. CBF parameters were analyzed in regions of interest with either prolonged or less prolonged mean transit time (MTT). Ratios of ipsi- vs contralateral CBF values were calculated and tested for correlation and differences between FAIR and DSC-MRI. FAIR-aCBF ratios correlated significantly with DSC-rCBF ratios. The mean FAIR-aCBF ratio was significantly lower than mean DSC-rCBF ratio in the area with prolonged MTT. In the area with less prolonged MTT, the mean FAIR-aCBF ratio and mean DSC-rCBF values did not differ significantly. We conclude that FAIR correlates with DSC-MRI if perfusion is preserved. FAIR provides lower CBF values than DSC-MRI if perfusion is reduced and MTT is prolonged. This probable underestimation of perfusion may be caused by transit delays. Care should be taken when quantifying CBF with FAIR and when comparing the results of FAIR- and DSC-MRI in areas with hypoperfusion. |
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Authors:
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J Hofmeijer; J Schepers; H B van der Worp; L J Kappelle; K Nicolay |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NMR in biomedicine Volume: 18 ISSN: 0952-3480 ISO Abbreviation: NMR Biomed Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2005-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 390-4 Citation Subset: IM |
Copyright Information:
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Copyright 2005 John Wiley & Sons, Ltd |
Affiliation:
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Department of Neurology, University Medical Center, Utrecht, The Netherlands. j.hofmeijer@neuro.azu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / blood supply*, pathology* Brain Ischemia / etiology*, pathology* Brain Mapping / methods* Cerebrovascular Circulation Infarction, Middle Cerebral Artery / complications* Magnetic Resonance Imaging / methods* Male Rats Rats, Inbred F344 Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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