Document Detail

Comparison of penile vascular effect induced by intracavernous injection of papaverine and prostaglandin E1.
MedLine Citation:
PMID:  2634727     Owner:  NLM     Status:  MEDLINE    
An intracavernous injection with papaverine or prostaglandin E1 (PGE1) combined with duplex ultrasonography is an objective technique to conduct a penile blood flow study (PBFS). Three hundred patients with impotence underwent papaverine (9-60 mg) induced PBFS at the University of California School of Medicine, San Francisco (UCSF), U.S.A. and another 80 patients with impotence received PGE1-induced (20 micrograms) PBFS at Veterans General Hospital-Taichung (VGH-TC), R.O.C. Preliminary evaluation of age, duration of disease and pre-injection diameter of cavernous arteries disclosed no significant difference in these 2 series. It was interesting to find that almost all parameters of vascular response to pavaverine vs PGE1 differed significantly, such as onset of response (6.5 +/- 6.5 vs 11.7 +/- 6.4 min, slower in the PGE1 group, p less than 0.001); post-injection diameter of cavernous arteries (right: 0.73 +/- 0.20 vs 0.79 +/- 0.18 mm, p = 0.03; left: 0.74 +/- 0.20 vs 0.82 +/- 0.21 mm, p = 0.005); diametral increment of cavernous arteries (right: 0.23 +/- 0.17 vs 0.33 +/- 0.17 mm, p less than 0.001; left: 0.24 +/- 0.17 vs 0.36 +/- 0.19 mm, p less than 0.001) and peak velocity (right: 27.5 +/- 16.1 vs 42.0 +/- 20.1 cm/sec, p less than 0.001; left: 28.9 +/- 15.9 vs 39.7 +/- 17.9 cm/sec, p less than 0.001). The side effects, primarily injection pain (23.8%, 19/80) in the PGE1 group and dizziness (3.0%, 9/300) in the papaverine group, were minor in these 2 series. Prolonged erection was not encountered in either series; however, immediate treatment was performed if a papaverine-induced erection lasted over 60 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)
T I Hwang; T F Lue; C R Yang; C L Chang; C H Chang; H C Wu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association     Volume:  88     ISSN:  0371-7682     ISO Abbreviation:  Taiwan Yi Xue Hui Za Zhi     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-06-05     Completed Date:  1990-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413761     Medline TA:  Taiwan Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  1038-41     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alprostadil / administration & dosage*
Blood Flow Velocity / drug effects
Erectile Dysfunction / diagnosis,  drug therapy
Middle Aged
Papaverine / administration & dosage*
Penile Erection / drug effects*
Penis / blood supply
Reg. No./Substance:
58-74-2/Papaverine; 745-65-3/Alprostadil

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