Document Detail

Comparison of peak expiratory flows and FEV1 in assessing immediate asthmatic reactions due to occupational agents.
MedLine Citation:
PMID:  10435478     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: FEV1 is more sensitive than PEF in assessing late asthmatic responses (LAR) after specific inhalation challenges (SIC) with occupational agents. As immediate asthmatic reactions (IAR) mainly involve proximal airways, PEF may, however, be as valid as FEV1. METHODS: Thirty-seven subjects who experienced an immediate fall in FEV1 of > or =20% during SIC with occupational agents and 20 subjects with fall of < or =10% in FEV1 were included. Both FEV1 and PEF were measured in a random order every 10 min for 1 h after exposure. We corrected PEF (PEFc) for inaccuracies of the mini-Wright meters by the Miller equation. RESULTS: Maximum changes in PEFc (30+/-11%) were not significantly different from changes in FEV1 (27+/-5%) (P=0.13). Their timings after exposure were 14+/-11 min and 17+/-17 min, respectively (P=0.4). High sensitivity (92%), specificity (95%), accuracy (93%), and positive predictive value (97%) were found for a 20% fall in PEFc to detect a significant IAR. Results were better and not influenced by meter inaccuracies with a cutoff point of 15% change in noncorrected PEF (PEFnc). An absolute decrease in PEF of 70 l/min gave a good discrimination between reactions with and without an asthmatic response. CONCLUSIONS: PEF is as satisfactory as FEV1 for detecting a significant IAR after exposure to an occupational agent if one considers a cutoff point of 1) 15% fall in PEF 2) 20% fall in PEFc 3) 20% fall and/or 70 l/min decrease in PEFnc.
K Weytjens; J L Malo; A Cartier; H Ghezzo; J P Delwiche; O Vandenplas
Related Documents :
7013568 - Clinical evaluation of high-frequency positive-pressure ventilation (hfppv) in patients...
2501278 - Effect of negative-pressure ventilation on lung water in permeability pulmonary edema.
6322268 - The early use of positive end expiratory pressure (peep) ventilation in emergency medic...
3030168 - The prone position improves arterial oxygenation and reduces shunt in oleic-acid-induce...
12729768 - Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on...
17460258 - Photo cross-linkable biodendrimers as ophthalmic adhesives for central lacerations and ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Allergy     Volume:  54     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-17     Completed Date:  1999-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  621-5     Citation Subset:  IM    
Department of Chest Medicine, Hôpital du Sacré-Coeur, Montréal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Allergens / immunology
Asthma / diagnosis*,  etiology,  immunology
Bronchial Provocation Tests
Evaluation Studies as Topic
Forced Expiratory Volume*
Occupational Exposure*
Peak Expiratory Flow Rate*
Reference Standards
Sensitivity and Specificity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Follow-up after systemic adverse reactions of immunotherapy.
Next Document:  Anaphylactic reaction to young garlic.