Document Detail

Comparison of peak exercise oxygen consumption and the Heart Failure Survival Score for predicting prognosis in women versus men.
MedLine Citation:
PMID:  17261406     Owner:  NLM     Status:  MEDLINE    
The Heart Failure Survival Score (HFSS) and peak exercise oxygen consumption (VO2) predict survival in ambulatory patients with heart failure and are used for selection for cardiac transplantation. However, the populations tested have predominately been men. To investigate if peak VO2 and the HFSS predict prognosis in women, we derived HFSS and measured peak VO2 in 274 women referred for cardiac transplantation and in 278 men matched by referral year. Seven HFSS parameters were obtained, including presence of coronary artery disease, left ventricular ejection fraction, heart rate, mean arterial blood pressure, peak VO2, presence of intraventricular conduction defects, and serum sodium. Subjects were divided into high-, medium-, and low-risk strata for HFSS and VO2 based on previous cutpoints. Survival curves were derived using Kaplan-Meier analysis and compared by log-rank analysis. Follow-up averaged 929 days. For women, 1-year event-free survival in the low- (>14), medium- (10.1 to 14), and high-risk (<10 ml/kg/min) VO2 strata was 93%, 84%, and 80%, respectively. For the HFSS, 1-year event-free survival in the low- (>or=8.10), medium- (7.20 to 8.09), and high-risk (<or=7.19) strata was 90%, 87%, and 67%, respectively. Survival curves for VO2 (p <0.01) and HFSS (p <0.001) demonstrated significant differences. In both genders, the low-risk groups for HFSS and VO2 can safely have transplantation deferred. Women had better survival than men for a given peak VO2. The HFSS was consistent between genders. In conclusion, peak VO2 and the HFSS are excellent parameters to predict survival in women with congestive heart failure. THE HFSS is more consistent than the peak VO2 between the genders.
Philip Green; Lars H Lund; Donna Mancini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-14
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-403     Citation Subset:  AIM; IM    
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
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MeSH Terms
Exercise / physiology*
Follow-Up Studies
Heart Failure / metabolism,  mortality*,  physiopathology
Middle Aged
Oxygen Consumption / physiology*
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Factors
Stroke Volume / physiology
Survival Rate / trends
United States / epidemiology
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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