Document Detail

Comparison of patients' compliance with prescribed oral and inhaled asthma medications.
MedLine Citation:
PMID:  8002686     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Noncompliance with medications is one of the most serious problems facing health care today. However, methods to measure compliance have many limitations. METHODS: To measure specific drug compliance and dosing frequency of two asthma medications, we used medical records data and pharmacy claims data from 276 patients who had concurrent prescriptions for inhaled anti-inflammatory agents and oral theophylline. Patients were randomly selected from the pharmacy claims data files of a health maintenance organization. The patients' medical records were reviewed, and records that did not contain clear documentation of the medication, dose, and dosing frequency were excluded. Data from the remaining 119 medical records were compared with data from pharmacy claims to calculate compliance rates for each medication. RESULTS: Our calculations showed that patients were significantly more compliant with prescribed theophylline medication than with two inhaled anti-inflammatory medications (P = .0001). No significant differences in compliance were found relative to prescribed dosing frequency (twice daily or less compared with three times daily or more) for either medication (P = .6517). CONCLUSIONS: Comparison of medical record data with pharmacy claims data is an effective indirect measure of patients' compliance with prescribed oral theophylline and inhaled anti-inflammatory agents. Additional interventions must be pursued for patients with asthma regarding adherence to regimens for their prescribed inhaled anti-inflammatory agents.
J S Kelloway; R A Wyatt; S A Adlis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  154     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-12     Completed Date:  1994-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1349-52     Citation Subset:  AIM; IM    
Asthma and Allergy Research Center, Park Nicollet Medical Center, Minneapolis, Minn.
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MeSH Terms
Administration, Inhalation
Administration, Oral
Adrenal Cortex Hormones / administration & dosage*
Asthma / drug therapy*
Cromolyn Sodium / administration & dosage
Drug Administration Schedule
Middle Aged
Patient Compliance*
Theophylline / administration & dosage*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 15826-37-6/Cromolyn Sodium; 58-55-9/Theophylline
Comment In:
Arch Intern Med. 1995 Mar 13;155(5):547-8   [PMID:  7864715 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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