Document Detail


Comparison of patient-controlled epidural bolus administration of 0.1% ropivacaine and 0.1% levobupivacaine, both with 0.0002% fentanyl, for analgesia during labour.
MedLine Citation:
PMID:  14725515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to compare the relative potencies and clinical characteristics of epidural ropivacaine and levobupivacaine in labour using patient-controlled epidural analgesia (PCEA). In a randomised double-blinded study, 60 ASA I or II primigravidae requesting epidural analgesia in early labour were allocated to receive either 0.1% ropivacaine with fentanyl 0.0002% or 0.1% levobupivacaine with 0.0002% fentanyl via a patient-controlled analgesia pump. Analgesia was established with 15 ml of study solution and maintained using 5-ml boluses of study solution with a 5-min lockout interval. There were no significant differences in onset time, duration and quality of analgesia, motor and sensory blockade, local anaesthetic consumption, mode of delivery, neonatal outcome or maternal satisfaction between the groups. We conclude that 0.1% ropivacaine with 0.0002% fentanyl and 0.1% levobupivacaine with 0.0002% fentanyl are clinically indistinguishable for labour analgesia and appear pharmacologically equipotent when using PCEA.
Authors:
N L Purdie; E M McGrady
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  59     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-16     Completed Date:  2004-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  AIM; IM    
Affiliation:
University Department of Anaesthesia, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK. niall.purdie@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Amides*
Analgesia, Epidural / methods*
Analgesia, Obstetrical / methods*
Analgesia, Patient-Controlled / methods*
Anesthetics, Combined
Anesthetics, Local
Bupivacaine* / analogs & derivatives
Double-Blind Method
Female
Fentanyl
Humans
Patient Satisfaction
Pregnancy
Pregnancy Outcome
Prospective Studies
Chemical
Reg. No./Substance:
0/Amides; 0/Anesthetics, Combined; 0/Anesthetics, Local; 0/levobupivacaine; 2180-92-9/Bupivacaine; 437-38-7/Fentanyl; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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