Document Detail


Comparison of parenteral iron sucrose and ferric chloride during erythropoietin therapy of haemodialysis patients.
MedLine Citation:
PMID:  20377770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To compare the effects of i.v. iron sucrose and Fe chloride on the iron indices of haemodialysis patients with anaemia. METHODS: One hundred and eight haemodialysis patients receiving recombinant human erythropoiesis-stimulating agent (ESA) (mean age 59.37 years) were enrolled and randomly assigned to an iron sucrose or an Fe chloride group. Iron supplements were administered at 100 mg/week during the first 4 weeks (loading dose). Ferritin and transferrin saturation (TSAT) were then measured and dose adjusted. Ninety-eight subjects completed treatment; 51 in the iron sucrose group and 47 in the Fe chloride group. Ferritin, TSAT, haematocrit (Hct), reticulocyte count, serum albumin, fractional clearance of urea (Kt/V) and intact parathyroid hormone (iPTH) were measured. RESULTS: There was no significant difference in baseline characteristics between the groups. Significant differences between the groups were observed in both iron indices and ESA dosage. Hct at week 24 (31.1% vs 29.7%, P = 0.006) and ferritin at week 20 (731.3 vs 631.7 ng/mL, P = 0.006) in the iron sucrose group were significantly higher than in the Fe chloride group. ESA dosage used in the iron sucrose group at week 8 was significantly lower than in the Fe chloride group (244.9 vs 322.6 U/kg per month, P = 0.003), and iron sucrose group received significantly lower iron dose than the Fe chloride group at week 8 (P = 0.005). CONCLUSION: Although the differences in ESA dosage, ferritin and iron dosage between two groups were found during the study period while similar results were shown at the end of 24 week study. Thus, iron sucrose and Fe chloride are safe and work equally well for haemodialysis patients.
Authors:
Chih-Jen Wu; Hsin-Chang Lin; Kun-Feng Lee; Chih-Kuang Chuang; Yi-Chou Chen; Han-Hsiang Chen
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Mackay Memorial Hospital, College of Medicine, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Anemia / drug therapy*
Chlorides / administration & dosage*
Female
Ferric Compounds / administration & dosage*
Hematinics / administration & dosage*
Humans
Infusions, Parenteral
Male
Middle Aged
Prospective Studies
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Chlorides; 0/Ferric Compounds; 0/Hematinics; 7705-08-0/ferric chloride; 8047-67-4/ferric oxide, saccharated

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