Document Detail

Comparison of the panicogenic effect of cholecystokinin 30-33 and carbon dioxide in panic disorder.
MedLine Citation:
PMID:  1908105     Owner:  NLM     Status:  MEDLINE    
1. Twenty-two patients who met DSM-III-R criteria for panic disorder received either cholecystokinin 30-33 (25 micrograms i.v.) or 33% carbon dioxide. 2. The principal outcome measures of the study included the number and sum intensity of panic symptoms and the incidence of panic attacks. 3. The incidence of panic attacks tended (P = .07) to be higher with cholecystokinin 30-33 than with carbon dioxide. Nevertheless, patients who panicked within each group did not differ significantly with regard to the number and sum intensity of symptoms or symptom profile. 4. That cholecystokinin 30-33 and 35% carbon dioxide induced panic attacks which were qualitatively and quantitatively similar suggest that these agents might act on distinct systems that have a final common target or a final common mechanism of action.
J Bradwejn; D Koszycki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-13     Completed Date:  1991-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-9     Citation Subset:  IM    
Department of Psychiatry, St. Mary's Hospital Centre, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Amino Acid Sequence
Carbon Dioxide / pharmacology*
Mental Disorders / chemically induced*
Molecular Sequence Data
Panic / drug effects*
Tetragastrin / pharmacology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 1947-37-1/Tetragastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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