| Comparison of the outcome of intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia in the first cycle: a report of case series and meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 15679616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate the outcome of intracytoplasmic sperm injection with fresh and cryopreserved-thawed testicular spermatozoa in the first cycle in patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), a total of 90 cases, 48 OA and 42 NOA were studied. All patients underwent sperm retrieval by testicular sperm extraction (TESE) while their wives received conventional ovarian hyperstimulation. The hormone levels, testicular histology, the rates of sperm retrieval, fertilization, implantation and pregnancy were analysed and evaluated. This study and other four similar studies were subjected to meta-analysis. Sperm retrieval was successful in 100% OA and 61% NOA. Fresh spermatozoa were used in 87.5% and 92.4% of OA and NOA cases respectively; while cryopreserved-thawed spermatozoa were used in 12.5% and 7.6% of OA and NOA, respectively. The fertilization, implantation and clinical pregnancy rates were 65.5%, 15% and 25% respectively in OA group, and 54.2%, 5% and 23.1% respectively in NOA group. Sperm status (fresh or thawed), male partner's age, female age and male serum follicle-stimulating hormone had no significant effect upon fertilization rate, implantation rate, or pregnancy rate per embryo transfer. The results of meta-analysis indicate that there is no statistically significant difference in clinical pregnancy rates between the two groups. There was a significantly higher fertilization rate among OA patients in all analysed studies (95% CI = 14.29-15.71, d.f. 832, T = 1.96). In conclusion, although the fertilization rate was significantly higher in the OA group in our study and from the given meta-analysis, there were some differences as regards pregnancy rates. Although the overall effect was more or less similar pregnancy rates in both subtypes of azoospermia, this may not be true if non-male infertility variables were controlled for in all studies. |
| | |
Authors:
|
Mohamed Ghanem; Nagwa I Bakr; Maha A Elgayaar; Shymaa El Mongy; Hanan Fathy; Abdel-Hamid A Ibrahim |
Related Documents
:
|
10404686 - Isolation of sperm storage tubules from the uterovaginal junction mucosa of the turkey. 6416316 - Gonadotropin secretion and testicular function in golden hamsters exposed to skeleton p... 9222006 - Efficient modification of intracytoplasmic sperm injection technique for cases with tot... 9457946 - A randomized, prospective analysis of five sperm preparation techniques before intraute... 558706 - The effects of denervation on the localization of delta5-3beta-hydroxysteroid dehydroge... 11053506 - Vitamin a or beta-carotene supplementation reduces symptoms of illness in pregnant and ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Meta-Analysis |
Journal Detail:
|
Title: International journal of andrology Volume: 28 ISSN: 0105-6263 ISO Abbreviation: Int. J. Androl. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-31 Completed Date: 2005-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8000141 Medline TA: Int J Androl Country: England |
Other Details:
|
Languages: eng Pagination: 16-21 Citation Subset: IM |
Affiliation:
|
Infertility Unit, Mansoura Integrated Fertility Center (MIFC), Mansoura, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Female Humans Male Oligospermia / therapy* Sperm Injections, Intracytoplasmic* Treatment Outcome* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.
Next Document: Reproductive decisions by couples undergoing artificial insemination with donor sperm for severe mal...