Document Detail


Comparison of one week with two week regimens of amphotericin B both followed by fluconazole in the treatment of cryptococcal meningitis among AIDS patients.
MedLine Citation:
PMID:  17128844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Amphotericin B treatment in cryptococcosis requires daily hospital visits or admission. Its toxicities and hospital costs have been concerned. Short course amphotericin B regimen warrants to be evaluated. OBJECTIVE: To compare the safety and efficacy of one-week (AmB1) with two-week (AmB2) amphotericin B both followed by fluconazole. MATERIAL AND METHOD: 57 AIDS with cryptococcal meningitis were randomly assigned to either AmB1 or AmB2. Microbiological and clinical clearances were the outcomes of the study. RESULTS: The treatment success at 6 weeks was 63.3% in AmB1 and 70.4% in AmB2 (p = 0.574). Clinical assessment at week 10 and renal toxicities were not significantly different between both regimens. Mortality rate was 14% however, 75% of deaths were in AmB2. CONCLUSION: AmB1 was comparably effective and safe as the standard AmB2 regimen in the treatment of AIDS related cryptococcal meningitis. It can be an alternative regimen to lower hospital based care and improve cost effective for source limiting health care centers.
Authors:
Somsit Tansuphaswadikul; Wirach Maek-a-Nantawat; Benjaluck Phonrat; Lamom Boonpokbn; Aneley Getahun Mctm; Punnee Pitisuttithum
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  89     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1677-85     Citation Subset:  IM    
Affiliation:
Bamrasnaradura Infectious Disease Institute, Department of Disease Control, Nonthaburi.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / drug therapy*
Acquired Immunodeficiency Syndrome / complications*
Adult
Amphotericin B / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Fluconazole / administration & dosage,  therapeutic use*
Humans
Male
Meningitis, Cryptococcal / drug therapy*
Prospective Studies
Thailand
Time Factors
Chemical
Reg. No./Substance:
1397-89-3/Amphotericin B; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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