| Comparison of one week with two week regimens of amphotericin B both followed by fluconazole in the treatment of cryptococcal meningitis among AIDS patients. | |
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MedLine Citation:
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PMID: 17128844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amphotericin B treatment in cryptococcosis requires daily hospital visits or admission. Its toxicities and hospital costs have been concerned. Short course amphotericin B regimen warrants to be evaluated. OBJECTIVE: To compare the safety and efficacy of one-week (AmB1) with two-week (AmB2) amphotericin B both followed by fluconazole. MATERIAL AND METHOD: 57 AIDS with cryptococcal meningitis were randomly assigned to either AmB1 or AmB2. Microbiological and clinical clearances were the outcomes of the study. RESULTS: The treatment success at 6 weeks was 63.3% in AmB1 and 70.4% in AmB2 (p = 0.574). Clinical assessment at week 10 and renal toxicities were not significantly different between both regimens. Mortality rate was 14% however, 75% of deaths were in AmB2. CONCLUSION: AmB1 was comparably effective and safe as the standard AmB2 regimen in the treatment of AIDS related cryptococcal meningitis. It can be an alternative regimen to lower hospital based care and improve cost effective for source limiting health care centers. |
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Authors:
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Somsit Tansuphaswadikul; Wirach Maek-a-Nantawat; Benjaluck Phonrat; Lamom Boonpokbn; Aneley Getahun Mctm; Punnee Pitisuttithum |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 89 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-28 Completed Date: 2007-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 1677-85 Citation Subset: IM |
Affiliation:
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Bamrasnaradura Infectious Disease Institute, Department of Disease Control, Nonthaburi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy* Acquired Immunodeficiency Syndrome / complications* Adult Amphotericin B / administration & dosage, therapeutic use* Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Female Fluconazole / administration & dosage, therapeutic use* Humans Male Meningitis, Cryptococcal / drug therapy* Prospective Studies Thailand Time Factors |
| Chemical | |
Reg. No./Substance:
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1397-89-3/Amphotericin B; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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