Document Detail

Comparison of ondansetron and tropisetron combined with droperidol for the prevention of emesis in women with a history of post-operative nausea and vomiting.
MedLine Citation:
PMID:  10434168     Owner:  NLM     Status:  MEDLINE    
The anti-emetic efficacy of prophylactic ondansetron and tropisetron in combination with a low dose of droperidol in patients with high probability for post-operative nausea and vomiting undergoing gynaecological laparoscopy was compared. Patients were randomly allocated in a double-blind manner to receive either ondansetron 8 mg (n = 45) or tropisetron 5 mg (n = 43) at the end of surgery. A standardized general anaesthetic technique was used, including droperidol 0.75 mg. The incidence of nausea was 36% and 49% (P = 0.28), and vomiting occurred in 13% and 14% of the patients in the ondansetron and tropisetron groups, respectively. The onset time for rescue medication was significantly sooner after tropisetron than ondansetron (3 h 18 min vs. 6 h 25 min; P = 0.007). There were no statistically significant differences in efficacy between prophylactic ondansetron and tropisetron combined with droperidol in a high-risk population. However, ondansetron appeared to be more effective in preventing post-operative nausea and vomiting in the early hours after surgery compared with tropisetron.
M Koivuranta; T I Ala-Kokko; R Jokela; P Ranta
Related Documents :
7813558 - Profiles of emetic action of cisplatin in the ferret: a potential model of acute and de...
7539668 - Results of a randomised, controlled, multicentre study of recombinant human granulocyte...
11050518 - Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postopera...
6672108 - The influence of choline chloride on murine hematopoiesis in vivo and in vitro.
24176228 - The polyphenol-rich baobab fruit (adansonia digitata l.) reduces starch digestion and g...
19160718 - Stability of admixtures of pethidine and metoclopramide in aqueous solution, 5% dextros...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  16     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-17     Completed Date:  1999-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  390-5     Citation Subset:  IM    
Department of Anaesthesiology, Oulu University Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, General
Antiemetics / administration & dosage*
Double-Blind Method
Droperidol / administration & dosage*
Drug Therapy, Combination
Gynecologic Surgical Procedures
Indoles / administration & dosage*
Middle Aged
Ondansetron / administration & dosage*
Postoperative Nausea and Vomiting / drug therapy,  prevention & control*
Risk Factors
Serotonin Antagonists / administration & dosage*
Reg. No./Substance:
0/Antiemetics; 0/Indoles; 0/Serotonin Antagonists; 548-73-2/Droperidol; 89565-68-4/tropisetron; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The onset of neuromuscular block at the masseter muscle as a predictor of optimal intubating conditi...
Next Document:  Factors determining end-expiratory alveolar pressure after cardiac surgery.