| Comparison of a once-a-day sustained-release morphine formulation with standard oral morphine treatment for cancer pain. | |
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MedLine Citation:
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PMID: 9262035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kadian/Kapanol (K) is a capsule formulation of morphine designed for 12- or 24-hourly dosing. This double-blind study compared the efficacy and safety of K every 24 hr to K every 12 hr and MS Contin tablets (MSC) every 12 hr. One hundred fifty-two patients with cancer pain were titrated to adequate analgesia with immediate-release morphine (IRM) solution. Stabilized patients were randonized to one of the three treatments for 7 +/- 1 days. Rescue medication was IRM tablets. Efficacy and safety were assessed by time to first remedication and total dose of rescue medication, pain scores, global assessments, and incidence of morphine-related side effects. Fifty-four patients were treated with K every 24 hr. 45 with K every 12 hr. and 53 with MSC every 12 hr. Mean age was 61 years and mean total daily dose of morphine was 138 mg. Forty-six percent of the K every 24 hr patients, 51% of the K every 12 hr patients, and 55% of the MSC every 12 hr patients required rescue medication on the final day. Time to remedication was 16.0 hr for K every 24 hr, 9.1 hr for K every 12 hr and 8.7 hr for MSC every 12 hr (P = 0.0010). Patient global assessment significantly favored K every 24 hr over MSC every 12 hr (P = 0.018). There were no statistically significant differences among the treatments for any morphine-related side effects when adjusted for baseline. K had efficacy and safety profiles similar to MSC every 12 hr but had the advantage of 12- or 24-hourly administration. |
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Authors:
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A Broomhead; R Kerr; W Tester; P O'Meara; C Maccarrone; R Bowles; P Hodsman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pain and symptom management Volume: 14 ISSN: 0885-3924 ISO Abbreviation: J Pain Symptom Manage Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-11 Completed Date: 1997-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8605836 Medline TA: J Pain Symptom Manage Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-73 Citation Subset: IM |
Affiliation:
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F.H. Faulding & Co. Limited, Adelaide, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Analgesics, Opioid / administration & dosage*, therapeutic use Delayed-Action Preparations Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Morphine / administration & dosage*, therapeutic use Neoplasms / drug therapy* Palliative Care* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Delayed-Action Preparations; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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