| Comparison of the offspring of three serial pregnancies during voluntary alcohol consumption in Sinclair (S-1) miniature swine. | |
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MedLine Citation:
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PMID: 6683364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The offspring of serial breedings of voluntary alcohol consuming Sinclair (S-1) miniature swine have been evaluated over the past three years. The first and second litters of 12 dams and the third litter of 6 dams were examined. All study animals had been consuming alcohol for at least 18 months prior to the first breeding. Alcohol consumption was continuous throughout the ninth study. Twelve non-alcohol-consuming sows were used as controls. The results of the study revealed a progressive decrease in mean litter size from controls of 6.66 in the control litters to 1.8 piglets per litter in the third litter born to alcohol-consuming dams. Perinatal deaths showed a progressive increase from 10% in the controls to 36.4% in the L3 litter. The birth weight showed a decline from a mean of 719 +/- 186 g in the control group to 467 +/- 122 g in the L3 litter. Abortions were not seen in control, first litter or second litter; however, there were 3 aborted fetuses in the third litter. Observation revealed no additional anomalies beyond the previous reports of anomalies seen in litters of alcohol-consuming S-1 miniature swine dams. |
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Authors:
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J D Dexter; M E Tumbleson; J D Decker; C C Middleton |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurobehavioral toxicology and teratology Volume: 5 ISSN: 0275-1380 ISO Abbreviation: Neurobehav Toxicol Teratol Publication Date: 1983 Mar-Apr |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8104162 Medline TA: Neurobehav Toxicol Teratol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 229-31 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking* Alcoholism / genetics* Animals Female Fetal Alcohol Syndrome / genetics* Humans Litter Size / drug effects Pregnancy Pregnancy, Animal / drug effects Swine Swine, Miniature |
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