Document Detail

Comparison of the offspring of three serial pregnancies during voluntary alcohol consumption in Sinclair (S-1) miniature swine.
MedLine Citation:
PMID:  6683364     Owner:  NLM     Status:  MEDLINE    
The offspring of serial breedings of voluntary alcohol consuming Sinclair (S-1) miniature swine have been evaluated over the past three years. The first and second litters of 12 dams and the third litter of 6 dams were examined. All study animals had been consuming alcohol for at least 18 months prior to the first breeding. Alcohol consumption was continuous throughout the ninth study. Twelve non-alcohol-consuming sows were used as controls. The results of the study revealed a progressive decrease in mean litter size from controls of 6.66 in the control litters to 1.8 piglets per litter in the third litter born to alcohol-consuming dams. Perinatal deaths showed a progressive increase from 10% in the controls to 36.4% in the L3 litter. The birth weight showed a decline from a mean of 719 +/- 186 g in the control group to 467 +/- 122 g in the L3 litter. Abortions were not seen in control, first litter or second litter; however, there were 3 aborted fetuses in the third litter. Observation revealed no additional anomalies beyond the previous reports of anomalies seen in litters of alcohol-consuming S-1 miniature swine dams.
J D Dexter; M E Tumbleson; J D Decker; C C Middleton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobehavioral toxicology and teratology     Volume:  5     ISSN:  0275-1380     ISO Abbreviation:  Neurobehav Toxicol Teratol     Publication Date:    1983 Mar-Apr
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104162     Medline TA:  Neurobehav Toxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-31     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking*
Alcoholism / genetics*
Fetal Alcohol Syndrome / genetics*
Litter Size / drug effects
Pregnancy, Animal / drug effects
Swine, Miniature

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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