Document Detail

Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen.
MedLine Citation:
PMID:  19097212     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R(1)) and effective transverse relaxation rate (R(*)(2)), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R(1) were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R(*)(2) occurred following pure oxygen in any organ. However, a significant increase in R(*)(2) was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R(1) and R(*)(2) were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology.
James P B O'Connor; Josephine H Naish; Alan Jackson; John C Waterton; Yvonne Watson; Sue Cheung; David L Buckley; Deirdre M McGrath; Giovanni A Buonaccorsi; Samantha J Mills; Caleb Roberts; Gordon C Jayson; Geoff J M Parker
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  61     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-02-27     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
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MeSH Terms
Administration, Inhalation
Carbon Dioxide / administration & dosage*,  pharmacokinetics*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Metabolic Clearance Rate
Organ Specificity
Oxygen / administration & dosage*,  pharmacokinetics*
Pattern Recognition, Automated / methods*
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
Grant Support
C19221/A6086//Cancer Research UK; C21247/A7473//Cancer Research UK; C237/A6295//Cancer Research UK; G0601746//Medical Research Council
Reg. No./Substance:
142M471B3J/Carbon Dioxide; 8063-77-2/carbogen; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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