| Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen. | |
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MedLine Citation:
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PMID: 19097212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R(1)) and effective transverse relaxation rate (R(*)(2)), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R(1) were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R(*)(2) occurred following pure oxygen in any organ. However, a significant increase in R(*)(2) was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R(1) and R(*)(2) were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology. |
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Authors:
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James P B O'Connor; Josephine H Naish; Alan Jackson; John C Waterton; Yvonne Watson; Sue Cheung; David L Buckley; Deirdre M McGrath; Giovanni A Buonaccorsi; Samantha J Mills; Caleb Roberts; Gordon C Jayson; Geoff J M Parker |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 61 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-24 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 75-83 Citation Subset: IM |
Affiliation:
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Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. james.o'connor@manchester.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Algorithms* Carbon Dioxide / administration & dosage*, pharmacokinetics* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Metabolic Clearance Rate Organ Specificity Oxygen / administration & dosage*, pharmacokinetics* Pattern Recognition, Automated / methods* Reference Values Reproducibility of Results Sensitivity and Specificity Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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C19221/A6086//Cancer Research UK; C21247/A7473//Cancer Research UK; C237/A6295//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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