Document Detail

Comparison of nifedipine and ritodrine for the treatment of preterm labor.
MedLine Citation:
PMID:  1814297     Owner:  NLM     Status:  MEDLINE    
Treatment of preterm labor with beta-sympathomimetics has been questioned because of the many maternal and fetal complications associated with its use. Nifedipine, a calcium antagonist, has been shown to suppress uterine activity in vitro and in vivo. A randomized prospective study was performed to compare the efficacy of nifedipine to ritodrine in the suppression of preterm labor. Data obtained from 42 women, of which 19 were randomized to the ritodrine group and 23 to the nifedipine group, were analyzed. Ritodrine and nifedipine proved to be equally effective in the suppression of preterm labor. However, the nifedipine group had fewer maternal and fetal complications.
L A Bracero; E Leikin; N Kirshenbaum; N Tejani
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of perinatology     Volume:  8     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-06-22     Completed Date:  1992-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, New York Medical College, Westchester County Medical Center, Valhalla 10595.
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MeSH Terms
Birth Weight
Fetus / drug effects
Infant, Newborn
Infant, Newborn, Diseases / epidemiology
Nifedipine / adverse effects,  therapeutic use*
Obstetric Labor, Premature / drug therapy*
Pregnancy Complications / epidemiology
Pregnancy Outcome
Prospective Studies
Ritodrine / adverse effects,  therapeutic use*
Tocolysis / methods*
Treatment Outcome
Reg. No./Substance:
21829-25-4/Nifedipine; 26652-09-5/Ritodrine

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