Document Detail

Comparison of newly developed inhalation anesthesia system and intraperitoneal anesthesia on the hemodynamic state in mice.
MedLine Citation:
PMID:  17827727     Owner:  NLM     Status:  MEDLINE    
KNI-472 is the first anesthetic system for mice and rats to incorporate a ventilator. It consists of a newly developed syringe pump-type vaporizer and gas monitor that can deliver accurate concentrations of anesthetic gas at an extremely low airflow. In this study, we compared the hemodynamic effects of isoflurane anesthesia using KNI-472 and intraperitoneal pentobarbital anesthesia. In the isoflurane anesthetic group, Institute of Cancer Research (ICR) mice were anesthetized with 5% isoflurane, followed by endotracheal intubation. Subsequently, they were ventilated mechanically, and anesthesia was maintained with 2% isoflurane for a 60-min period using KNI-472. In the pentobarbital anesthetic group, the ICR mice were anesthetized by an intraperitoneal injection of sodium pentobarbital (70 mg/kg). In isoflurane anesthesia, the heart rate (HR) and mean blood pressure (MBP) were stable. In contrast, in pentobarbital anesthesia, MBP decreased in the first stage after the initiation of anesthesia, after which it gradually increased. The intra-group variability in the estimated skin blood flow (SBF) was higher in the pentobarbital anesthesia than that in the isoflurane anesthesia. The PaO(2) and PaCO(2) values at 15 min after the initiation of pentobarbital anesthesia revealed hypoxia and hypercapnia compared with isoflurane anesthesia. In this study, isoflurane anesthesia using KNI-472, unlike pentobarbital anesthesia, did not induce changes in MBP, SBF, or blood gases. The changes induced by pentobarbital anesthesia were attributed to a change in the depth of anesthesia with time. These results indicate that inhalation anesthesia using KNI-472 is suitable in research on the hemodynamic state in mice.
Yoshikazu Matsuda; Kazumasa Ohsaka; Hidekazu Yamamoto; Katsuhiko Natsume; Shirokazu Hirabayashi; Masayoshi Kounoike; Masaaki Inoue
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  30     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1716-20     Citation Subset:  IM    
Department of Integrative Physiology & Bio-System Control, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
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MeSH Terms
Anesthesia, Inhalation / instrumentation*
Anesthetics, Inhalation
Blood Pressure / drug effects*
Carbon Dioxide / blood
Heart Rate / drug effects*
Hypnotics and Sedatives
Injections, Intraperitoneal
Mice, Inbred ICR
Oxygen / blood
Regional Blood Flow / drug effects
Respiration, Artificial
Skin / blood supply
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Hypnotics and Sedatives; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 76-74-4/Pentobarbital; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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