Document Detail


Comparison of a new neuromuscular transmission monitor compressomyograph with mechanomyograph.
MedLine Citation:
PMID:  18238840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS: The two monitors were randomly allocated to the left or right hands of 16 patients. T1, first twitch of the train-of-four (TOF) expressed as percentage of control response, and the TOF ratio (T4:t1) were used to evaluate the neuromuscular block produced by rocuronium 0.6 mg kg(-1). RESULTS: The CMG monitor exhibited no pre-relaxation reverse fade (T4>T1) or T1 exceeding 100%. There was no significant difference in mean (SD) onset time, Dur(25) (time to T1 25% recovery), or Dur(0.9) (time to 0.9 TOF ratio recovery) measured by the CMG [2.4 (0.9), 22.6 (4.1), 43.1 (10.3) min, respectively] compared with MMG [2.1 (0.9), 22.9 (3.3), 43.3 (10.0) min, respectively]. According to Bland and Altman analysis, the bias (upper and lower limits of agreement) for T1% was -0.3% (+13.4% and -13.8%) and for TOF ratio was -0.009 (+0.068 and -0.085). CMG showed 100% sensitivity and 75% specificity in indicating full relaxation for tracheal intubation, and 80% sensitivity with 86% specificity in predicting MMG 0.9 TOF ratio. CONCLUSIONS: The CMG could be a reliable clinical monitor in the daily anaesthesia practice that does not require time to set up or rigid support of the arm.
Authors:
A A Dahaba; H Bornemann; B Holst; G Wilfinger; H Metzler
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2008-01-31
Journal Detail:
Title:  British journal of anaesthesia     Volume:  100     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  344-50     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 29, A-8036 Graz, Austria. ashraf.dahaba@meduni-graz.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Androstanols / pharmacology
Epidemiologic Methods
Equipment Design
Female
Humans
Male
Middle Aged
Monitoring, Intraoperative / instrumentation*,  methods
Myography / instrumentation*,  methods
Neuromuscular Blockade*
Neuromuscular Junction / drug effects*,  physiology
Neuromuscular Nondepolarizing Agents / pharmacology
Synaptic Transmission / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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