| Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. | |
| | |
MedLine Citation:
|
PMID: 20381469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hippocampal neurogenesis can be regulated by extrinsic factors, such as exercise and antidepressants. While there is evidence that the selective serotonin reuptake inhibitor (SSRI) fluoxetine enhances neurogenesis, the new dual serotonergic-noradrenergic reuptake inhibitor (SNRI) duloxetine has not been evaluated in this context. In addition, it is unclear whether effects of antidepressants and running on cell genesis and behavior are of similar magnitude in mice. Here, we assessed neurogenesis and open-field behavior in 2-month-old female C57Bl/6 mice after 28days of treatment with either fluoxetine (18mg/kg), duloxetine (2, 6 or 18mg/kg) or exercise. New cell survival, as measured by 5-bromo-2'-deoxyuridine (BrdU)-labeled cells, was enhanced by 200% in the running group only. Both running and fluoxetine, but not duloxetine, increased the percentage of new cells that became neurons. In the open-field test, animals treated with either drug spent less time in the center than controls and runners. In addition, fluoxetine treatment resulted in reduced locomotor activity. Together, these data show that the neurogenic response to exercise is much stronger than to antidepressants and imply a low likelihood that anxiolytic effects of these drugs are mediated by adult neurogenesis in C57Bl/6 mice. |
| | |
Authors:
|
Michael W Marlatt; Paul J Lucassen; Henriette van Praag |
Related Documents
:
|
18674809 - Ampk and ppardelta agonists are exercise mimetics. 20303389 - Effects of moderate exercise on cigarette smoke exposure-induced hippocampal oxidative ... 133799 - Physical training and connective tissues in young mice-heart. 3202159 - Exercise regulation of triiodothyronine metabolism. 1641869 - The effects of aluminum ingestion on intestinal cadmium absorption, lipid peroxidation ... 12464089 - Spontaneous mechanical activity and evoked responses in isolated gastric preparations f... 3760769 - Kinetics of oxygen uptake and release by red blood cells of chicken and duck. 8173759 - Inflammatory effects of ozone in the upper airways of subjects with asthma. 20402569 - L-tryptophan supplementation can decrease fatigue perception during an aerobic exercise... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2010-04-08 |
Journal Detail:
|
Title: Brain research Volume: 1341 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-11 Completed Date: 2011-01-25 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 93-9 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier B.V. |
Affiliation:
|
Swammerdam Institute for Life Science-Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects*, physiology Cell Proliferation / drug effects Cell Survival / drug effects, physiology Female Fluoxetine / pharmacology* Hippocampus / cytology, drug effects, physiology Mice Mice, Inbred C57BL Motor Activity / drug effects*, physiology Neurogenesis / drug effects, physiology Neuronal Plasticity / drug effects, physiology Neurons / cytology, drug effects*, physiology* Physical Conditioning, Animal / physiology Serotonin Uptake Inhibitors / pharmacology* Thiophenes / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
ZIA AG000328-02/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Uptake Inhibitors; 0/Thiophenes; 116539-58-3/duloxetine; 54910-89-3/Fluoxetine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of exercise-induced arousal on cognitive task performance: a meta-regression analysis.
Next Document: Ginsenoside Rg1 Promotes Glutamate Release Via a Calcium / Calmodulin-dependent Protein Kinase II-de...