Document Detail

Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice.
MedLine Citation:
PMID:  20381469     Owner:  NLM     Status:  MEDLINE    
Hippocampal neurogenesis can be regulated by extrinsic factors, such as exercise and antidepressants. While there is evidence that the selective serotonin reuptake inhibitor (SSRI) fluoxetine enhances neurogenesis, the new dual serotonergic-noradrenergic reuptake inhibitor (SNRI) duloxetine has not been evaluated in this context. In addition, it is unclear whether effects of antidepressants and running on cell genesis and behavior are of similar magnitude in mice. Here, we assessed neurogenesis and open-field behavior in 2-month-old female C57Bl/6 mice after 28days of treatment with either fluoxetine (18mg/kg), duloxetine (2, 6 or 18mg/kg) or exercise. New cell survival, as measured by 5-bromo-2'-deoxyuridine (BrdU)-labeled cells, was enhanced by 200% in the running group only. Both running and fluoxetine, but not duloxetine, increased the percentage of new cells that became neurons. In the open-field test, animals treated with either drug spent less time in the center than controls and runners. In addition, fluoxetine treatment resulted in reduced locomotor activity. Together, these data show that the neurogenic response to exercise is much stronger than to antidepressants and imply a low likelihood that anxiolytic effects of these drugs are mediated by adult neurogenesis in C57Bl/6 mice.
Michael W Marlatt; Paul J Lucassen; Henriette van Praag
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-04-08
Journal Detail:
Title:  Brain research     Volume:  1341     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2011-01-25     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Swammerdam Institute for Life Science-Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Behavior, Animal / drug effects*,  physiology
Cell Proliferation / drug effects
Cell Survival / drug effects,  physiology
Fluoxetine / pharmacology*
Hippocampus / cytology,  drug effects,  physiology
Mice, Inbred C57BL
Motor Activity / drug effects*,  physiology
Neurogenesis / drug effects,  physiology
Neuronal Plasticity / drug effects,  physiology
Neurons / cytology,  drug effects*,  physiology*
Physical Conditioning, Animal / physiology
Serotonin Uptake Inhibitors / pharmacology*
Thiophenes / pharmacology*
Grant Support
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 0/Thiophenes; 116539-58-3/duloxetine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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