Document Detail


Comparison of natural surfactant and brief liquid ventilation rescue treatment in very immature lambs. Clinical and physiological correlates.
MedLine Citation:
PMID:  8724656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of rescue therapy with modified porcine surfactant (Curosurf) or brief perfluorocarbon liquid ventilation on pulmonary gas exchange, mechanics and structure in very immature lambs. Both rescue strategies produced an improvement in arterial oxygenation and were able to support CO2 elimination. Histology showed unevenly inflated lungs in all but tidal-liquid-ventilated lambs. We speculate that due to immature lung architecture and relatively high permeability, previous exposure to gas ventilation impeded full effectiveness of both rescue modalities, perhaps prophylactic surfactant or liquid ventilation could be a better alternative.
Authors:
A Valls-i-Soler; M R Wolfson; N Kechner; R Foust; T H Shaffer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  69     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1996  
Date Detail:
Created Date:  1996-10-17     Completed Date:  1996-10-17     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  275-83     Citation Subset:  IM    
Affiliation:
Department of Physiology, Temple University School of Medicine, Philadelphia, Pa., USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn*
Biological Agents*
Female
Fluorocarbons*
Gestational Age
Lung / anatomy & histology
Phospholipids*
Pulmonary Gas Exchange
Pulmonary Surfactants / therapeutic use*
Respiration, Artificial*
Respiratory Mechanics
Sheep
Chemical
Reg. No./Substance:
0/Biological Agents; 0/Fluorocarbons; 0/Phospholipids; 0/Pulmonary Surfactants; KE3U2023NP/poractant alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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