| Comparison of myocardial infarction with sequential ligation of the left anterior descending artery and its diagonal branch in dogs and sheep. | |
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MedLine Citation:
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PMID: 12757035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a comparison of the effects of myocardial infarction in dogs and sheep using sequential ligation of the left anterior descending artery (LAD) and its diagonal branch (DA), with hemodynamic, ultrasonographic and pathological evaluations. Five animals were used in each group. After surgical preparation, the LAD was ligated at a point approximately 40% of the distance from the apex to the base of the heart, and after one hour, the DA was ligated at the same level. Hemodynamic and ultrasonographic measurements were performed preligation, 30 minutes after LAD ligation, and 1 hour after DA ligation. As a control, two animals in each group were used for the simultaneous ligation of the LAD and the DA. Two months after the coronary ligation, the animals were evaluated as previously, and killed for postmortem examination of their hearts. All seven animals in the dog group survived the experimental procedures, while in the sheep group only animals with sequential ligation of the LAD and DA survived. Statistically significant decreases in systemic arterial blood pressure and cardiac output, and an increase in the pulmonary artery capillary wedge pressure (PACWP) were observed one hour after sequential ligation of the LAD and its DA in the sheep, while only systemic arterial pressures decreased in the dog. Ultrasonographic analyses demonstrated variable degrees of anteroseptal dyskinesia and akinesia in all sheep, but in no dogs. Data two months after coronary artery ligation showed significant increases in central venous pressure, pulmonary artery pressure, and PACWP in the sheep, but not in the dog. Left ventricular end-diastolic dimension and left ventricular end-systolic dimension in ultrasonographic studies were also increased only in the sheep. Pathologically, the well-demarcated thin-walled transmural anteroseptal infarcts with chamber enlargement were clearly seen in all specimens of sheep, and only-mild-to-moderate chamber enlargements with endocardial fibrosis were observed in the dog hearts. In conclusion, this study confirms that the dog is not a suitable model for myocardial infarction with failure by coronary artery ligation despite negligent operative mortality, when compared directly with an ovine model. |
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Authors:
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W G Kim; Y C Shin; S W Hwang; C Lee; C Y Na |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The International journal of artificial organs Volume: 26 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-21 Completed Date: 2003-08-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: Italy |
Other Details:
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Languages: eng Pagination: 351-7 Citation Subset: IM |
Affiliation:
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Department of Thoracic and Cardiovascular Surgery and Heart Research Institute, Seoul National University College of Medicine, Seoul, Korea. wongon@plaza.snu.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / pathology, physiopathology*, surgery* Disease Models, Animal* Dogs* Echocardiography Heart / physiopathology Hemodynamics / physiology Ligation Myocardial Infarction / pathology, physiopathology*, ultrasonography* Myocardium / pathology Reproducibility of Results Sheep* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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