Document Detail


Comparison of the myocardial clearance of endothelial progenitor cells injected early versus late into reperfused or sustained occlusion myocardial infarction.
MedLine Citation:
PMID:  22736429     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Stem cell transplantation following AMI has shown promise for the repair or reduction of the amount of myocardial injury. There is some evidence that these treatment effects appear to be directly correlated to cell residence time. This study aims to assess the effects of (a) the timing of stem cell injection following myocardial infarction, and (b) flow milieu, on cell residence times at the site of transplantation by comparing three time points (day of infarction, week 1 and week 4-5), and two models of acute myocardial infarction (sustained occlusion or reperfusion). Twenty-one dogs received 2 injections of 30 million endothelial progenitor cells. The first injections were administered by epicardial (n = 8) or endocardial injection (n = 13) either on the day of infarction (n = 15) or at 1 week (n = 6). The second injections were administered by only endocardial injection (n = 18) 4 weeks following the first injection. Cell clearance half-lives were comparable between early and late injections. However, transplants into sustained occlusion infarcts resulted in slower cell clearance 77.1 ± 6.1 (n = 18) versus reperfused 59.4 ± 2.9 h (n = 21) p = 0.009. Sustained occlusion infarcts had longer cell retention in comparison to reperfusion whereas the timing of injection did not affect clearance rates. If the potential for myocardial regeneration associated with cell transplantation is, at least in part, linked to cell residence times, then greater benefit may be observed with transplants into infarcts associated with persistent coronary artery occlusion.
Authors:
Andrea J Mitchell; Eric Sabondjian; Kimberley J Blackwood; Jane Sykes; Lela Deans; Qingping Feng; Robert Z Stodilka; Frank S Prato; Gerald Wisenberg
Related Documents :
16970059 - Contrast echocardiography of right atrial mass due to hepatocellular carcinoma.
487549 - Two-dimensional echocardiographic demonstration of left atrial thrombi in patients with...
17592279 - Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in sync...
2070289 - Leiomyosarcoma of the left atrium: case report and review of the literature.
9175529 - Unique association of a rapidly growing right atrial myxoma in a child with double-outl...
24016759 - Tbx18 regulates development of the epicardium and coronary vessels.
17698429 - Role of atrial remodeling in patients with atrial fibrillation.
4031309 - Pseudosimultaneous fast and slow pathway conduction: a common electrophysiologic findin...
10149229 - Intraoperative echocardiography for surgical repair of the aortic valve and left ventri...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  -     ISSN:  1875-8312     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Speckle tracking echocardiography in acute myocarditis.
Next Document:  Screening for MYO15A gene mutations in autosomal recessive nonsyndromic, GJB2 negative Iranian deaf ...