| Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men. | |
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MedLine Citation:
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PMID: 11153727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The present study was designed to compare the absolute myocardial blood flow (MBF) after intravenous dipyridamole infusion with that during dobutamine-atropine administration in normal healthy male volunteers. BACKGROUND: Both safety and usefulness of dobutamine-atropine stress in myocardial perfusion imaging have been reported. However, no information exists on whether the magnitude ofhyperemia achieved with dipyridamole and dobutamine-atropine is comparable. METHODS: Myocardial blood flow was measured with positron emission tomography and 15O-labeled water in 20 healthy young men (23 +/- 3 years) 1) at baseline, 2) after dipyridamole infusion (0.56 mg/kg over 4 min), and 3) during dobutamine (40 microg/kg/min) and atropine (0.25 to 1.0 mg) infusion. RESULTS: The MBF was significantly increased during dipyridamole infusion and during dobutamine-atropine stress compared with at rest (4.33 +/- 1.23 and 5.89 +/- 1.58 vs. 0.67 +/- 0.16 ml/min/g, respectively, p < 0.0001). Moreover, dobutamine-atropine infusion produced greater MBF compared with dipyridamole (p = 0.0011), while coronary vascular resistance did not differ significantly after dipyridamole administration and during dobutamine-atropine infusion (17.6 +/- 7.9 vs. 18.6 +/- 5.6 mm Hg/[ml/min/g], respectively). CONCLUSIONS: Near maximal coronary vasodilatation caused by dipyridamole is attainable using dobutamine and atropine in young healthy volunteers. Dobutamine in conjunction with atropine is no less effective than dipyridamole in producing myocardial hyperemia. |
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Authors:
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E Tadamura; H Iida; K Matsumoto; M Mamede; S Kubo; H Toyoda; T Shiozaki; T Mukai; Y Magata; J Konishi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 37 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-10 Completed Date: 2001-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 130-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Japan. et@kuhp.kyoto-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atropine / diagnostic use* Coronary Circulation / drug effects*, physiology Dipyridamole / diagnostic use* Dobutamine / diagnostic use* Humans Infusions, Intravenous Male Reference Values Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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34368-04-2/Dobutamine; 51-55-8/Atropine; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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