Document Detail


Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol.
MedLine Citation:
PMID:  22465835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While induction of food refusal by the trichothecene mycotoxin deoxynivalenol (DON) has been described in several animal models, much less is known about the anorectic effects of structurally related 8-ketotrichothecenes, 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX) and nivalenol (NIV). Here, we compared the capacities of these congeners to induce anorexia in the mouse. As previously observed for DON, anorectic responses to 3-ADON and 15-ADON in the B6C3F1 female mouse following both intraperitoneal (IP) and oral exposure were transient, lasting only a few hours, with food intake recovering to control levels within 16 h. For both ADONs, the no observed adverse effect levels (NOAEL) and lowest observed adverse effect levels (LOAEL) were 0.5 and 1mg/kg bw following IP exposure, respectively, and 1 and 2.5mg/kg bw after oral exposure, respectively. In contrast, food refusal persisted from 48 to 96 h following IP and oral exposure to FX and NIV. For both IP and oral FX exposure, the NOAEL was 0.025 mg/kg bw and LOAEL was 0.25mg/kg bw, whereas the NOAELs and LOAELs for NIV were 0.01 and 0.1mg/kg bw, respectively, after IP exposure and 0.1 and 1mg/kg bw, respectively, following oral exposure. Both these data and a prior DON study suggest that anorectic responses to 8-ketotrichothecenes were always greater when administered IP as compared to oral exposure and follow an approximate rank order of NIV>FX>DON≈3-ADON≈15-ADON for IP exposure and FX>NIV>DON≈3-ADON≈15-ADON for oral exposure. Toxic potency data such as is described here will be applicable to future comparative risk assessments for this important group of trichothecene mycotoxins.
Authors:
Wenda Wu; Brenna M Flannery; Yoshiko Sugita-Konishi; Maiko Watanabe; Haibin Zhang; James J Pestka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-03-22
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  50     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-10-09     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2056-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants*
Dose-Response Relationship, Drug
Eating / drug effects
Female
Fusarium / chemistry
Mice
Mice, Inbred Strains
Mycotoxins / toxicity*
No-Observed-Adverse-Effect Level
Trichothecenes / pharmacology,  toxicity*
Grant Support
ID/Acronym/Agency:
ES03553/ES/NIEHS NIH HHS; R01 ES003358/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Mycotoxins; 0/Trichothecenes; 23255-69-8/fusarenon-X; 23282-20-4/nivalenol; 50722-38-8/3-acetyldeoxynivalenol; 51481-10-8/deoxynivalenol; 88337-96-6/15-acetyldeoxynivalenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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