Document Detail

Comparison of multislice computed tomography with intravascular ultrasound for detection and characterization of coronary artery plaques: a systematic review.
MedLine Citation:
PMID:  18586427     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Multislice computed tomography (MSCT) is a novel non-invasive test for detection and analysis of coronary artery plaques. A systematic review was conducted of the literature to compare MSCT with IVUS as the reference standard for assessing coronary artery plaques. MATERIALS AND METHODS: We performed a literature search in the online database MEDLINE, which was accessed at on 9th April 2008. RESULTS: The search identified 14 studies with 340 patients (mean age 59+/-5 years). The systematic review revealed a sensitivity of MSCT on the lesion level (n=1779 coronary plaques) on the order of 90% (range from 87 to 92%) in comparison to IVUS. Per-segment analysis (n=356) yielded a lower sensitivity of 81-86%. In the per-vessel analysis (n=90), MSCT had a better sensitivity and specificity for the RCA (83-89% and 92-100%) and the LAD (83-87% and 93%) than for the LCX (71-85% and 77-89%), and on the vessel level and the cross-section analysis MSCT was more sensitive for calcified plaques than for non-calcified plaque. It is noteworthy that most studies provide only incomplete data on technical and methodological parameters such as radiation exposure and patient characteristics. CONCLUSION: MSCT is an accurate and reliable test for detection of coronary artery plaques in comparison to IVUS with limitations in regards to the LCX and non-calcified plaques. Studies published thus far are limited by the sample sizes and methodological quality issues.
Ivonne Springer; Marc Dewey
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Review     Date:  2008-06-30
Journal Detail:
Title:  European journal of radiology     Volume:  71     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  IM    
Department of Radiology, Charité, Medical School, Humboldt-Universität zu Berlin, Germany.
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MeSH Terms
Coronary Angiography / methods*
Coronary Artery Disease / diagnosis*
Echocardiography / methods*
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*
Ultrasonography, Interventional / methods*

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