Document Detail

Comparison of mouse and rabbit lung damage exposure to 30 kHz ultrasound.
MedLine Citation:
PMID:  8059491     Owner:  NLM     Status:  MEDLINE    
Twenty-four mice and sixteen rabbits were evaluated at one exposure duration (10 min) and at three exposure acoustic pressure levels (0, 100 and 145 kPa) at an ultrasonic frequency of 30 kHz, continuous wave for the purpose of testing whether there was a species difference in the degree of sensitivity to ultrasound-induced lung damage. This study was undertaken because it was hypothesized that the mouse may not be an acceptable or suitable animal model for studies that examine the effects of ultrasound on lung tissue for purposes of extrapolating or estimating the degree of potential damage in other species. The rabbit was selected for comparison to the mouse because the rabbit exhibited sufficient physiological and morphological differences from those of the mouse to test this hypothesis. Using exactly the same exposure conditions and lung assessment criteria, it appeared that the mouse lung was more sensitive to ultrasound-induced damage than that of the rabbit by a factor of between 2.8 and 3.6. Lung lesions in mice and rabbits were similar in character, but were much more severe and extensive in mice. Lesions in both species consisted of intraalveolar hemorrhage that appeared as dark red to red-black areas that were visible on the pleural surfaces and that extend within the lung parenchyma.
W D O'Brien; J F Zachary
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  20     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-13     Completed Date:  1994-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-307     Citation Subset:  IM    
Department of Electrical and Computer Engineering, University of Illinois, Urbana 61801.
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MeSH Terms
Hemorrhage / pathology*
Lung / pathology*
Lung Diseases / etiology,  pathology*
Mice, Inbred C3H
Species Specificity
Time Factors
Ultrasonics / adverse effects*

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