| Comparison of mirtazapine and fluoxetine in the treatment of major depressive disorder: a double-blind, randomized trial. | |
| | |
MedLine Citation:
|
PMID: 15811165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Depression is an international public health problem. The aim of this study was to compare the efficacy and tolerability of mirtazapine and fluoxetine treatment in a sample population consisting of Iranian patients suffering major depressive disorder. METHODS: Thirty-six inpatients and outpatients with a diagnosis of major depressive disorder (Diagnostic and Statistical Manual of Mental Disorders-IV) and a score > or = 18 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17) were randomly assigned to 6 weeks of treatment with mirtazapine (30 mg/day) or fluoxetine (20 mg/day). Efficacy was assessed by HAM-D-17. Information about adverse events was obtained by questioning of participants and/or their examination. Assessments were performed at weeks 0, 1, 2, 3, 4 and 6. RESULTS: Sixteen of mirtazapine-treated patients and fifteen of fluoxetine-treated patients completed the 6-week study period. Both treatment groups were well matched at baseline with respect to demographic and disease characteristics. Both drugs showed a significant improvement over the 6 weeks of treatment (P < 0.001). There was no statistically significant difference between the mean +/- SEM HAM-D scores of two groups at weeks 1, 2, 3, 4, and at the end point. There were no significant differences between two groups in terms of response to treatment (> or = 50% decrease from baseline in HAM-D-17 total score) and remission (HAM-D-17 score of < or = 7). None of the differences in reported adverse events was statistically significant. CONCLUSION: In this study, mirtazapine and fluoxetine were equally effective and well tolerated after 6 weeks of treatment in patients with major depressive disorder. |
| | |
Authors:
|
H Amini; S Aghayan; S A Jalili; S Akhondzadeh; O Yahyazadeh; M Pakravan-Nejad |
Related Documents
:
|
21621265 - Stressful events, stress perception and treatment outcomes in patients with depressive ... 2932485 - The treatment of depression in patients with epilepsy. a double-blind trial. 22021945 - The contribution of deficits in emotional clarity to stress responses and depression. 347885 - Maprotiline and doxepin in the treatment of depression. a double-glind multicentre comp... 22426505 - A comparison of psychosocial risk factors between 3 groups of cardiovascular disease pa... 15576515 - Efficacy of penicillin for dental pain without overt infection. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of clinical pharmacy and therapeutics Volume: 30 ISSN: 0269-4727 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-04-06 Completed Date: 2005-11-03 Revised Date: 2008-05-28 |
Medline Journal Info:
|
Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
|
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. amini-hom@sina.tums.ac.ir |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Depressive Disorder, Major / diagnosis, drug therapy*, physiopathology Diagnostic and Statistical Manual of Mental Disorders Double-Blind Method Drug Administration Schedule Female Fluoxetine / administration & dosage, adverse effects, therapeutic use* Humans Inpatients Male Mianserin / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Middle Aged Outpatients Oxazepam / administration & dosage Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
24219-97-4/Mianserin; 54910-89-3/Fluoxetine; 604-75-1/Oxazepam; 61337-67-5/mirtazapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method.
Next Document: Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critica...