Document Detail


Comparison of mild stimulation and conventional stimulation in ART outcome.
MedLine Citation:
PMID:  19834718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To provide a treatment for particular condition that is the most effective treatment with the least risk and cost for the patient we compared the efficacy of using clomiphene 100 mg + delayed low dose gonadotropin + flexible GnRH antagonist administration for ovarian stimulation protocol and GnRH agonist + gonadotropin for stimulation protocol in IVF outcome. METHODS: Clinical outcome of 243 women with regularly menstruation who were candidate for IVF. They had undergone stimulation with GnRH agonist and gonadotropin (group A) or clomiphene citrate, gonadotropin and GnRH antagonist (group B). Main outcome was ongoing pregnancy. RESULTS: There were no significant difference in mean age, cause of infertility, basal FSH, BMI, duration of infertility, endometrial thickness on the day HCG administration in two groups. The number of recovered oocytes, obtained embryos, transferred embryos, peak of estradiol on the day HCG administration and OHSS were significantly higher in group A. Significantly more patients in control group had embryos for cryopreservation. There were no significant difference in clinical pregnancy rate and ongoing pregnancy rate between two groups. CONCLUSION: Clomiphene + delayed low dose gonadotropin + flexible GnRH - antagonist stimulation is an acceptable alternative protocol for IVF in patients with regularly menstruation.
Authors:
Mohammad Ali Karimzadeh; Shahnaz Ahmadi; Homa Oskouian; Elham Rahmani
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-10-16
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  281     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Science, Bouali Ave., Safaieh, Yazd, Iran. prof_karimzade@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Clomiphene / administration & dosage
Female
Fertility Agents, Female / administration & dosage*
Fertilization in Vitro
Gonadotropin-Releasing Hormone / agonists,  antagonists & inhibitors
Gonadotropins / administration & dosage*
Humans
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Prospective Studies
Chemical
Reg. No./Substance:
0/Fertility Agents, Female; 0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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