Document Detail

Comparison of mild stimulation and conventional stimulation in ART outcome.
MedLine Citation:
PMID:  19834718     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To provide a treatment for particular condition that is the most effective treatment with the least risk and cost for the patient we compared the efficacy of using clomiphene 100 mg + delayed low dose gonadotropin + flexible GnRH antagonist administration for ovarian stimulation protocol and GnRH agonist + gonadotropin for stimulation protocol in IVF outcome. METHODS: Clinical outcome of 243 women with regularly menstruation who were candidate for IVF. They had undergone stimulation with GnRH agonist and gonadotropin (group A) or clomiphene citrate, gonadotropin and GnRH antagonist (group B). Main outcome was ongoing pregnancy. RESULTS: There were no significant difference in mean age, cause of infertility, basal FSH, BMI, duration of infertility, endometrial thickness on the day HCG administration in two groups. The number of recovered oocytes, obtained embryos, transferred embryos, peak of estradiol on the day HCG administration and OHSS were significantly higher in group A. Significantly more patients in control group had embryos for cryopreservation. There were no significant difference in clinical pregnancy rate and ongoing pregnancy rate between two groups. CONCLUSION: Clomiphene + delayed low dose gonadotropin + flexible GnRH - antagonist stimulation is an acceptable alternative protocol for IVF in patients with regularly menstruation.
Mohammad Ali Karimzadeh; Shahnaz Ahmadi; Homa Oskouian; Elham Rahmani
Related Documents :
1986968 - Endometrial histology after first trimester spontaneous abortion.
22854208 - Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy.
9021378 - Endometrial pattern in diethylstilboestrol-exposed women undergoing in-vitro fertilizat...
8907758 - Evaluation of reproductive function in turkana women with enzyme immunoassays of urinar...
16676568 - Retzius' space haematoma after spontaneous delivery: a case report.
18947788 - Can we prevent hypospadias?
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-10-16
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  281     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Science, Bouali Ave., Safaieh, Yazd, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clomiphene / administration & dosage
Fertility Agents, Female / administration & dosage*
Fertilization in Vitro
Gonadotropin-Releasing Hormone / agonists,  antagonists & inhibitors
Gonadotropins / administration & dosage*
Ovulation Induction / methods*
Pregnancy Rate
Prospective Studies
Reg. No./Substance:
0/Fertility Agents, Female; 0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The development of excitatory neurons in the chick cloaca.
Next Document:  Uterine compression sutures, an update: review of efficacy, safety and complications of B-Lynch sutu...