Document Detail

Comparison of middle cerebral artery trunk occlusion by silicone cylinder embolization and by trapping.
MedLine Citation:
PMID:  6827345     Owner:  NLM     Status:  MEDLINE    
The authors produced occlusion of the middle cerebral artery (MCA) trunk in dogs by two methods: silicone cylinder embolization and trapping. Comparative analyses of the clinicopathological features in these models, extending from the acute to chronic stage, were performed. Within 24 hours after embolization, the brain exhibited swelling without macroscopic infarction. Microangiograms revealed impaired filling in the deep areas of the brain with midline shift. At 4 to 7 days after embolization, the animals showed major neurological deficits, evident deep cerebral infarction, and poorly perfused areas in the deep cerebrum with prominent midline shift. At 3 to 4 weeks after embolization, the neurological deficits improved and the affected regions showed cavities or localized lesions. Microangiograms demonstrated hypervascular areas with abnormal vessels in the affected cerebrum. On the other hand, trapping of the MCA trunk produced mild neurological deficits, although there was no evidence of macroscopic lesions or impairment of filling. This study shows that silicone cylinder embolization in the MCA trunk produces a reliable and reproducible deep cerebral infarction in dogs.
Y Okada; T Shima; N Yokoyama; T Uozumi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  58     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  AIM; IM    
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MeSH Terms
Brain / pathology*
Cerebral Arteries / pathology
Cerebral Infarction / etiology*,  pathology
Silicone Elastomers
Reg. No./Substance:
0/Silicone Elastomers

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