| Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study. | |
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MedLine Citation:
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PMID: 18990368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of the microdose flare-up and multiple-dose antagonist protocols for poor-responder patients in intracytoplasmic sperm injection-ET cycles. DESIGN: A randomized, prospective study. SETTING: Center for assisted reproductive technology in Turkey. PATIENT(S): Ninety patients with poor ovarian response in a minimum of two previous IVF cycles. INTERVENTION(S): All women were prospectively randomized into two groups by computer-assisted randomization. The patients in group 1 were stimulated according to the microdose flare-up protocol (n = 45), while the patients in group 2 were stimulated according to antagonist multiple-dose protocol (n = 45). MAIN OUTCOME MEASURE(S): The mean number of mature oocytes retrieved was the primary outcome measure, and fertilization rate, implantation rate per embryo, and clinical pregnancy rates were secondary outcome measures. RESULT(S): The mean age of the women, the mean duration of infertility, basal FSH level, and the number of previous IVF cycles were similar in both groups. The total gonadotropin dose used was significantly higher in group 2, while the number of oocytes retrieved was significantly greater in group 1. Although the fertilization and clinical pregnancy rates were nonsignificantly higher in group 1 compared with group 2, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). CONCLUSION(S): The microdose flare-up protocol seems to have a better outcome in poor-responder patients, with a significantly higher mean number of mature oocytes retrieved and higher implantation rate. |
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Authors:
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Aygul Demirol; Timur Gurgan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-11-05 |
Journal Detail:
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Title: Fertility and sterility Volume: 92 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-08-27 Revised Date: 2010-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 481-5 Citation Subset: IM |
Affiliation:
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Clinic Women Health, Infertility and IVF Center, Hacettepe University Faculty of Medicine, Ankara, Turkey. ademirol@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy Contraceptives, Oral, Hormonal / administration & dosage* Embryo Transfer / methods Female Fertilization in Vitro / methods* Gonadotropin-Releasing Hormone / administration & dosage* Hormone Antagonists / administration & dosage* Humans Infertility, Female / therapy* Ovulation Induction / methods Pregnancy Pregnancy Outcome* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Hormonal; 0/Hormone Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2010 May 1;93(7):e35; author reply e36
[PMID:
20303479
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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