Document Detail

Comparison of methods for measuring albumin in peritoneal dialysis and hemodialysis patients.
MedLine Citation:
PMID:  8678068     Owner:  NLM     Status:  MEDLINE    
Serum albumin levels have been used extensively as an indicator of morbidity in patients with end-stage renal disease. Recent evidence suggests that albumin levels vary considerably in hemodialysis patients depending on the laboratory method used, but formulas for comparing albumin values by different methods have not been developed. We prospectively evaluated the effects of measuring albumin by three different methods on paired plasma and serum from 23 patients on continuous ambulatory peritoneal dialysis (CAPD) and 53 patients on chronic maintenance hemodialysis. Plasma and serum gave virtually identical results independent of method used. In CAPD patients, bromcresol green and nephelometry gave nearly identical albumin measurements through the entire range of plasma levels. In contrast, bromcresol purple gave values that were 9.9 percent +/- 1.3 percent lower (P < 0.05). Hemodialysis patients showed a similar pattern with close agreement between bromcresol green and nephelometry, but bromcresol purple gave lower albumin levels by 19.1 percent +/- 1.2 percent (P < 0.05). The discrepancy in albumin in CAPD patients was significantly less than in the hemodialysis patients (P < 0.05), suggesting that there were fewer interfering substances in the blood of CAPD patients than in hemodialysis patients. Linear regression analysis was used to develop simple formulas for comparing albumin values obtained by the different methods in CAPD and hemodialysis patients. These studies show that values for albumin in blood vary significantly by method of analysis in CAPD and hemodialysis patients. By the use of these formulas, it becomes possible to compare albumin values between centers using different methods for the purpose of quality management.
R Joseph; L Tria; R T Mossey; A G Bellucci; L U Mailloux; M A Vernace; I Miller; B M Wilkes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  27     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-08-14     Completed Date:  1996-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-72     Citation Subset:  IM    
Division of Nephrology and Hypertension, North Shore University Hospital, Manhasset, NY 11030, USA.
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MeSH Terms
Analysis of Variance
Dye Dilution Technique / statistics & numerical data
Evaluation Studies as Topic
Middle Aged
Nephelometry and Turbidimetry / methods,  statistics & numerical data
Peritoneal Dialysis, Continuous Ambulatory* / statistics & numerical data
Prospective Studies
Renal Dialysis* / statistics & numerical data
Serum Albumin / analysis*
Reg. No./Substance:
0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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