Document Detail

Comparison of methods of measurements of oxygen consumption in mechanically ventilated patients with multiple trauma: the Fick method versus indirect calorimetry.
MedLine Citation:
PMID:  10834679     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to compare the measurements of whole body oxygen consumption determined by the Fick method and by indirect calorimetry in mechanically ventilated patients with multiple trauma. DESIGN: A prospective, correlational, within-subjects design. SETTING: Surgical intensive care unit of a Level I trauma center. PATIENTS: Thirty-eight mechanically ventilated adults with multiple injuries who received a pulmonary artery catheter within 24 hrs of admission to the surgical intensive care unit. MEASUREMENTS AND MAIN RESULTS: After the initial resuscitation, simultaneous measurements of oxygen consumption (V(O2) by the reverse Fick equation and by indirect calorimetry were performed every 6 hrs for 24 hrs in normothermic patients who were at rest for at least 30 mins. At each measurement period, the mean V(O2) values determined by indirect calorimetry were significantly greater than the mean V(O2) values determined by the Fick method (time 1: 172+/-38 vs. 125+/-47 mL/min/m2, p < .0001; time 2: 170+/-31 vs. 130+/-48 mL/min/m2, p < .0001; time 3: 170+/-32 vs. 132+/-53 mL/min/m2, p < .0001; time 4: 169+/-29 vs. 130+/-60 mL/min/m2, p < .0002). By using the Bland and Altman technique, the mean bias was 41+/-3.95 mL/min/m2. Correlation coefficients of VO2 values between methods of measurements were statistically significant (r2 = .32, p = .0001; r2 = .32, p = .0001; r2 = .33, p = .0001; r2 = .18, p = .0001). CONCLUSIONS: Indirect calorimetry should be the preferred standard for measurement of oxygen consumption in severely injured patients.
C D Epstein; J R Peerless; J E Martin; M A Malangoni
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  28     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1363-9     Citation Subset:  AIM; IM    
Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Calorimetry, Indirect*
Catheters, Indwelling*
Critical Care
Middle Aged
Multiple Organ Failure / physiopathology,  therapy
Multiple Trauma / physiopathology,  therapy*
Oxygen Consumption / physiology*
Predictive Value of Tests
Prospective Studies
Pulmonary Artery
Respiration, Artificial*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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