| Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. | |
| | |
MedLine Citation:
|
PMID: 20473763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS). METHODS: A total of 69 consecutive infertile, anovulatory women with PCOS were enrolled in this prospective, non-randomized trial. The women were prescribed either 1,700 mg/day metformin or CC with a starting dose of 50 mg/day up to 150 mg/day for a period of six consecutive cycles. RESULTS: Metformin and CC groups were followed for a total of 136 and 94 cycles, respectively. Metformin group had lower rates of ovulation when compared with CC group (32.3 vs. 60.6%, respectively; p = 0.004). There was no statistical difference in pregnancy rates per cycle between the treatment groups (8 vs. 11.7%, respectively; p = 0.33) leading to similar cumulative pregnancy rates (36.6 vs. 35.4%, respectively; p = 0.45). No difference was observed among the abortion rates (10 vs. 10%, respectively; p > 0.05) between the groups. DISCUSSION: Although metformin and CC are two effective first-line approaches for improving pregnancy rates in anovulatory PCOS women, CC is associated with higher rates of ovulation. |
| | |
Authors:
|
Safak Baran; Murat Api; Behiye Pinar Cilesiz Goksedef; Ahmet Cetin |
Related Documents
:
|
2774063 - Ecology of a semi-isolated population of adult anopheles freeborni: abundance, trophic ... 8671233 - A prospective study of early pregnancy loss. 8112733 - Maternal cell contamination in amniotic fluid samples as a consequence of the sampling ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article Date: 2010-05-16 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: 282 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-07 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
|
Languages: eng Pagination: 439-43 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Istanbul, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anovulation / complications, drug therapy, etiology Clomiphene / therapeutic use* Female Fertility Agents, Female / therapeutic use* Humans Hypoglycemic Agents / therapeutic use* Infertility, Female / complications, drug therapy*, etiology Metformin / therapeutic use* Ovulation / drug effects Ovulation Induction* Polycystic Ovary Syndrome / complications* Pregnancy Pregnancy Rate Prospective Studies Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Fertility Agents, Female; 0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patients' awareness of postoperative adhesions: results from a multi-centre study and online survey.
Next Document: Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?