Document Detail

Comparison of metal release from various metallic biomaterials in vitro.
MedLine Citation:
PMID:  15193877     Owner:  NLM     Status:  MEDLINE    
To investigate the metal release of each base and alloying elements in vitro, SUS316L stainless steel, Co-Cr-Mo casting alloy, commercially pure Ti grade 2, and Ti-6Al-4V, V-free Ti-6Al-7Nb and Ti-15Zr-4Nb-4Ta alloys were immersed in various solutions, namely, alpha-medium, PBS(-), calf serum, 0.9% NaCl, artificial saliva, 1.2 mass% L-cysteine, 1 mass% lactic acid and 0.01 mass% HCl for 7d. The difference in the quantity of Co released from the Co-Cr-Mo casting alloy was relatively small in all the solutions. The quantities of Ti released into alpha-medium, PBS(-), calf serum, 0.9% NaCl and artificial saliva were much lower than those released into 1.2% L-cysteine, 1% lactic acid and 0.01% HCl. The quantity of Fe released from SUS316L stainless steel decreased linearly with increasing pH. On the other hand, the quantity of Ti released from Ti materials increased with decreasing pH, and it markedly attenuated at pHs of approximately 4 and higher. The quantity of Ni released from stainless steel gradually decreased with increasing pH. The quantities of Al released from the Ti-6Al-4V and Ti-6Al-7Nb alloys gradually decreased with increasing pH. A small V release was observed in calf serum, PBS(-), artificial saliva, 1% lactic acid, 1.2% l-cysteine and 0.01% HCl. The quantity of Ti released from the Ti-15Zr-4Nb-4Ta alloy was smaller than those released from the Ti-6Al-4V and Ti-6Al-7Nb alloys in all the solutions. In particular, it was approximately 30% or smaller in 1% lactic acid, 1.2% L-cysteine and 0.01% HCl. The quantity of (Zr + Nb + Ta) released was also considerably lower than that of (Al + Nb) or (Al + V) released. Therefore, the Ti-15Zr-4Nb-4Ta alloy with its low metal release in vitro is considered advantageous for long-term implants.
Yoshimitsu Okazaki; Emiko Gotoh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  26     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-06-14     Completed Date:  2005-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-21     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Ltd.
Institute of Mechanical Systems Engineering, National Institute of Advanced Industrial Science and Technology, Ecology-oriented Structural Material Group, 2-1 Namiki 1-chome, Tsukuba, Ibaraki 305-8564, Japan.
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MeSH Terms
Biocompatible Materials / analysis,  chemistry*
Biomimetic Materials / chemistry*
Body Fluids / chemistry*
Hydrogen-Ion Concentration
Materials Testing / methods*
Metals / chemistry
Stainless Steel / analysis,  chemistry*
Titanium / analysis,  chemistry*
Vitallium / analysis,  chemistry*
Reg. No./Substance:
0/Biocompatible Materials; 0/Metals; 12597-68-1/Stainless Steel; 12629-02-6/Vitallium; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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