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Comparison of metabolite profiles in U87 glioma cells and mesenchymal stem cells.
MedLine Citation:
PMID:  21605622     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gas chromatography-mass spectrometry (GC-MS) profiles were generated from U87 glioma cells and human mesenchymal stem cells (hMSC). 37 metabolites representing glycolysis intermediates, TCA cycle metabolites, amino acids and lipids were selected for a detailed analysis. The concentrations of these metabolites were compared and Pearson correlation coefficients were used to calculate the relationship between pairs of metabolites. Metabolite profiles and correlation patterns differ significantly between the two cell lines. These profiles can be considered as a signature of the underlying biochemical system and provide snap-shots of the metabolism in mesenchymal stem cells and tumor cells.
Authors:
Kathrin Jürchott; Ke-Tai Guo; Gareth Catchpole; Kristen Feher; Lothar Willmitzer; Christian Schichor; Joachim Selbig
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-14
Journal Detail:
Title:  Bio Systems     Volume:  -     ISSN:  1872-8324     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0430773     Medline TA:  Biosystems     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Affiliation:
AG Bioinformatics, Institute for Biochemistry and Biology, University of Potsdam, Germany.
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