Document Detail


Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor.
MedLine Citation:
PMID:  23312455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. Is preterm cervical remodeling caused by the same mechanisms that cause cervical remodeling at term, and are these changes accelerated in time? This question has been pondered by obstetricians seeking strategies to prevent preterm labor for many years. Mice represent an informative model of preterm birth. Thus, in this review we discuss the recent findings from mouse models that identify and characterize the initiators and cellular effectors of cervical remodeling at term and preterm labor/delivery. These studies suggest that similarities and differences exist between term and preterm cervical remodeling. Complement is an initiator or mediator in preterm labor/delivery, but is not involved in the physiological process that leads to term delivery. Therefore, complememt constitutes a specific and selective target for potentially preventing preterm delivery, thus improving neonatal health.
Authors:
Juan M Gonzalez; Roberto Romero; Guillermina Girardi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-10
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  97     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-09-04     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cervix Uteri / drug effects,  immunology*,  pathology
Complement System Proteins / immunology*
Disease Models, Animal
Female
Humans
Labor, Obstetric / immunology*
Mice
Molecular Targeted Therapy
Obstetric Labor, Premature / drug therapy,  immunology*
Pregnancy
Wound Healing
Grant Support
ID/Acronym/Agency:
ZIA HD002401-17/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins
Comments/Corrections

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