Document Detail


Comparison of the mechanism of action of vitamin D3 and 1 alpha-OH D3 under conditions of experimental hypercalcemia.
MedLine Citation:
PMID:  223375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comparison of the mechanism of action Vitamin D3 and 1 alpha-OH D3 under conditions of experimental hypercalcemia. Acta Physiol. Pol. 1979, 30 (2): 313--318. The hypercalcemic effect of supraphysiological doses of Vitamin D and 1 alpha-OH D3 were compared applying an animal model. Changes in serum calcium of animals with normal dietary calcium supplementation and those under conditions of calcium depletion were analyzed. Dietary calcium is necessary for the hypercalcemic effect of Vitamin D, whereas in case of 1 alpha-OH D3 calcium is mobilized not only from the dietary but also from some other sources. The analysis of the hypercalcemia kinetics in the Vitamin D and 1 alpha-OH D3 treated animals indicated that the kidney 1 hydroxylase of 25 hydroxycholecalciferol is an important step in the hypercalcemia preventing mechanism.
Authors:
I Dargiel-Targońska; Z Cieślukowski; R S Lorenc
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta physiologica Polonica     Volume:  30     ISSN:  0044-6033     ISO Abbreviation:  Acta Physiol Pol     Publication Date:    1979 Mar-Apr
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985166R     Medline TA:  Acta Physiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / blood*
Calcium, Dietary / metabolism
Cholecalciferol / pharmacology*
Hydroxycholecalciferols / pharmacology*
Hypercalcemia / metabolism*
Kinetics
Phosphates / metabolism
Rats
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/Hydroxycholecalciferols; 0/Phosphates; 67-97-0/Cholecalciferol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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