Document Detail


Comparison of the measures of pulsatile arterial function between asymptomatic younger adult smokers and former smokers: the Bogalusa Heart Study.
MedLine Citation:
PMID:  16942930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cigarette smoking, an established cardiovascular (CV) disease risk factor, is known to impair pulsatile arterial function. However, information is scant in this regard on asymptomatic younger adult former smokers. As part of the Bogalusa Heart Study, the pulsatile arterial function was examined noninvasively in 278 nonsmokers, 277 current smokers, and 104 former smokers, aged 18 to 44 years, mean 36.4 years by radial artery pressure pulse contour analysis. Compared to current smokers, former smokers had higher body mass index (BMI, 29.6 v 27.7 kg/m2, P=.02), after adjusting for age, ethnicity, and sex, and higher levels of glucose (94.8 v 85.3 mg/dL, P=.008) and insulin (15.0 v 10.9 microU/mL, P=.01), after adjusting for age, ethnicity, sex, and BMI. Compared to nonsmokers, former smokers had similar BMI, but marginally high glucose (P=.08) and insulin (P=.11). With respect to measures of pulsatile arterial function, nonsmokers versus current smokers versus former smokers had similar large artery compliance (15.2 v 15.1 v 15.1 mL/mmHgx10) but increased (P=.01) small artery compliance after smoking cessation (6.6 v 5.8 v 6.5 mL/mmHgx100), and decreased (P=.03) systemic vascular resistance after smoking cessation (1300.5 v 1376.9 v 1292.2 dynes.sec.cm-5), and increases in small artery compliance (P=.0003) and decreases in systemic vascular resistance (P=.01) were found among those who quit smoking 10 years or more, after adjusting for ethnicity, sex, age, glucose, insulin, and alcohol use. These findings, although cross-sectional in nature, indicate the potential for improving arterial wall dynamics after smoking cessation in younger adults.
Authors:
Hong Li; Sathanur R Srinivasan; Gerald S Berenson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of hypertension     Volume:  19     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-31     Completed Date:  2007-05-09     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  897-901     Citation Subset:  IM    
Affiliation:
Tulane Center for Cardiovascular Health, Tulane School of Public Health & Tropical Medicine, New Orleans, Louisiana 70112-2824, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Biological Markers / blood
Blood Pressure
Cardiovascular Diseases / blood,  epidemiology,  etiology,  physiopathology
Endothelium, Vascular / physiopathology
Female
Humans
Louisiana / epidemiology
Male
Pulsatile Flow*
Pulse
Radial Artery / physiopathology
Risk Factors
Smoking / adverse effects,  blood,  epidemiology,  physiopathology*
Smoking Cessation*
Vascular Resistance
Wrist / blood supply
Grant Support
ID/Acronym/Agency:
AG-16592/AG/NIA NIH HHS; HD-043820/HD/NICHD NIH HHS; HL-38844/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers

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