Document Detail

Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis.
MedLine Citation:
PMID:  21363978     Owner:  NLM     Status:  MEDLINE    
Angiostrongylus cantonensis meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid samples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.
Bárbara Padilla-Docal; Alberto J Dorta-Contreras; Juan M Moreira; Luiggi Martini-Robles; Jenny Muzzio-Aroca; Fernando Alarcón; María Esther Magraner-Tarrau; Raisa Bu-Coifiu-Fanego
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  84     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-04-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-10     Citation Subset:  AIM; IM    
Laboratorio Central de Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Dr. Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, Havana, Cuba.
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MeSH Terms
Child, Preschool
Cuba / epidemiology
Ecuador / epidemiology
Immunoglobulins / cerebrospinal fluid*,  metabolism
Meningitis / cerebrospinal fluid*,  epidemiology,  immunology,  parasitology*
Strongylida Infections / cerebrospinal fluid,  epidemiology,  immunology,  metabolism
Young Adult
Reg. No./Substance:

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