Document Detail

Comparison of magnetic resonance perfusion imaging versus invasive fractional flow reserve for assessment of the hemodynamic significance of epicardial coronary artery stenosis.
MedLine Citation:
PMID:  17437733     Owner:  NLM     Status:  MEDLINE    
This study evaluated whether first-pass perfusion cardiovascular magnetic resonance (FP-CMR) could predict the hemodynamic significance of epicardial coronary artery stenosis as defined by invasively determined fractional flow reserve at coronary angiography. In 19 patients with known coronary artery disease (CAD), the hemodynamic relevance of 22 stenoses (mean angiographic severity 73 +/- 9%) was determined using fractional flow reserve measurements (cutoff 0.75). Results were compared with a territorial index of myocardial perfusion reserve (MPR) derived from FP-CMR. In addition, 9 age-matched patients with low prevalence of risk factors and without CAD at angiography served as a control group. A cutoff of 1.5 for MPR separated hemodynamically relevant from nonrelevant stenoses with a sensitivity and specificity of 92% and 92%, respectively. The area under the receiver-operator characteristic curve was 0.97. In the patient group, territories supplied by arteries without significant stenosis (<or=50%) showed a lower MPR compared with the control group (p <0.0001), suggesting the presence of microvascular dysfunction. In conclusion, FP-CMR may be useful for assessment of the hemodynamic relevance of angiographically undetermined CAD.
Harald P Kühl; Marcus Katoh; Christiane Buhr; Gabriele A Krombach; Rainer Hoffmann; Tienush Rassaf; Mirja Neizel; Arno Buecker; Malte Kelm
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-02-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1090-5     Citation Subset:  AIM; IM    
Medical Clinic I, University Hospital RWTH, Aachen, Germany.
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MeSH Terms
Aged, 80 and over
Area Under Curve
Case-Control Studies
Coronary Angiography* / statistics & numerical data
Coronary Stenosis / diagnosis*,  physiopathology
Coronary Vessels / physiopathology
Fractional Flow Reserve, Myocardial / physiology*
Magnetic Resonance Imaging / methods*,  statistics & numerical data
Microcirculation / physiopathology
Middle Aged
ROC Curve
Risk Factors
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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