Document Detail

Comparison of magnetic resonance imaging and transesophageal echocardiography in detection of thrombus in the left atrial appendage.
MedLine Citation:
PMID:  12970519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: A noninvasive technique of visualizing the left atrial appendage (LAA) and its thrombus in patients with atrial fibrillation would be of great interest. This study examined the utility of MRI for the assessment of thrombus in the LAA. METHODS: We evaluated 50 subjects with nonrheumatic continuous atrial fibrillation and a history of cardioembolic stroke. Each patient received an MRI and a transesophageal echocardiography (TEE) on the same day for thrombus detection in the LAA. Both double- and triple-inversion recovery sequences were used for the MRI evaluations. RESULTS: In all subjects, the LAA was readily visualized with MRI. High-intensity masses in the LAA were clearly distinguishable from the LAA wall in the triple-inversion recovery sequences. Concordance between detection of high-intensity mass with MRI and thrombus with TEE was high: no mass (MRI), no thrombus (TEE), 31 patients; mass (MRI), thrombus (TEE), 16 patients; and mass (MRI), no thrombus (TEE), 3 patients (overall kappa=0.876, SE=0.068). CONCLUSIONS: MRI is a noninvasive and reproducible modality for thrombus detection in the LAA of patients with nonrheumatic continuous atrial fibrillation and previous cardioembolic stroke.
Hideo Ohyama; Naohisa Hosomi; Tsutomu Takahashi; Katsufumi Mizushige; Kunihiko Osaka; Masakazu Kohno; James A Koziol
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-09-11
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  34     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2003-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2436-9     Citation Subset:  IM    
Second Department of Internal Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-Cho, Kagawa 761-0793, Japan.
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MeSH Terms
Aged, 80 and over
Atrial Appendage / pathology,  ultrasonography*
Atrial Fibrillation / complications,  diagnosis*,  ultrasonography
Echocardiography, Transesophageal*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Middle Aged
Predictive Value of Tests
Recurrence / prevention & control
Reproducibility of Results
Stroke / etiology,  prevention & control
Thrombosis / complications,  diagnosis*,  ultrasonography

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