Document Detail

Comparison of magnetic resonance imaging in Alzheimer's disease, vascular dementia and normal aging.
MedLine Citation:
PMID:  1592074     Owner:  NLM     Status:  MEDLINE    
MRI scans of 27 patients with probable Alzheimer's disease (mean age 68.2 years), 31 patients with vascular dementia (mean age 69.9 years) and 18 normal controls (mean age 66.3 years) were compared to evaluate possible distinguishing parenchymal abnormalities among these groups. Atrophy was quantitated by subjective rating, linear and volumetric measurements. A number of findings were significantly more common in vascular dementia than in the other subsets. These included (1) basal ganglionic/thalamic hyperintense foci, (2) thromboembolic infarctions, (3) confluent white matter and (4) irregular periventricular hyperintensities. Signal abnormalities on intermediate T2-weighted scans in the uncal-hippocampal or insular cortex were frequently and almost exclusively noted in Alzheimer's disease. Moderate and severe cortical and ventricular atrophy and a third ventricular to intracranial width ratio larger than 7% were good discriminators between demented groups and normally aging controls. Selective atrophy measurements, however, failed to separate dementia syndromes. These results suggest that MRI has the potential to increase the accuracy of the clinical diagnosis of Alzheimer's disease and vascular dementia.
R Schmidt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European neurology     Volume:  32     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-01     Completed Date:  1992-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Department of Neurology, Karl Franzens University Graz, Austria.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis*
Brain / pathology
Dementia, Multi-Infarct / diagnosis
Dementia, Vascular / diagnosis*
Diagnosis, Differential
Magnetic Resonance Imaging*
Middle Aged
Neuropsychological Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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