| Comparison of magnetic resonance imaging in Alzheimer's disease, vascular dementia and normal aging. | |
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MedLine Citation:
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PMID: 1592074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MRI scans of 27 patients with probable Alzheimer's disease (mean age 68.2 years), 31 patients with vascular dementia (mean age 69.9 years) and 18 normal controls (mean age 66.3 years) were compared to evaluate possible distinguishing parenchymal abnormalities among these groups. Atrophy was quantitated by subjective rating, linear and volumetric measurements. A number of findings were significantly more common in vascular dementia than in the other subsets. These included (1) basal ganglionic/thalamic hyperintense foci, (2) thromboembolic infarctions, (3) confluent white matter and (4) irregular periventricular hyperintensities. Signal abnormalities on intermediate T2-weighted scans in the uncal-hippocampal or insular cortex were frequently and almost exclusively noted in Alzheimer's disease. Moderate and severe cortical and ventricular atrophy and a third ventricular to intracranial width ratio larger than 7% were good discriminators between demented groups and normally aging controls. Selective atrophy measurements, however, failed to separate dementia syndromes. These results suggest that MRI has the potential to increase the accuracy of the clinical diagnosis of Alzheimer's disease and vascular dementia. |
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Authors:
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R Schmidt |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European neurology Volume: 32 ISSN: 0014-3022 ISO Abbreviation: Eur. Neurol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-01 Completed Date: 1992-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 164-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Karl Franzens University Graz, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis* Brain / pathology Dementia, Multi-Infarct / diagnosis Dementia, Vascular / diagnosis* Diagnosis, Differential Female Humans Magnetic Resonance Imaging* Male Middle Aged Neuropsychological Tests |
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