| Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension. | |
| | |
MedLine Citation:
|
PMID: 19927151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In general, treatment with most angiotensin receptor blockers (ARBs) increases plasma angiotensin II (Ang II) level because of a lack of negative feedback on renin activity. Olmesartan is a potential ARB inducing activation of angiotensin-converting enzyme 2 (ACE2) that hydrolyzes Ang II to Ang 1-7, and has shown a beneficial effect on ventricular remodeling. Indeed, a previous study reported that olmesartan treatment resulted in decreased plasma levels of Ang II and aldosterone. However, there has not yet been a study showing the relationship of chronic effects of olmesartan on Ang II and the left ventricular mass index (LVMI) in comparison with those of other ARB.A total of 50 stable outpatients with essential hypertension who had received candesartan for more than 1 year were randomized into two groups: control group (n=25): continuous candesartan treatment at a stable dose; and olmesartan group (n=25): candesartan (8 mg day(-1)) was changed to olmesartan given at a dose of 20 mg day(-1). There was no difference in the baseline characteristics between the two groups. In the control group, there were no significant changes in blood pressure, LVMI or biomarkers during 12 months of study. In the olmesartan group, blood pressure did not change and plasma levels of Ang II decreased during 12 months of study, whereas LVMI was significantly decreased after 12 months (135+/-36 vs. 123+/-29 g m(-2); P<0.01).These findings indicate that replacing candesartan with olmesartan decreased LVMI in association with a sustained decrease of plasma Ang II over a 12-month period without changing blood pressure or plasma aldosterone in patients with essential hypertension. |
| | |
Authors:
|
Takayoshi Tsutamoto; Keizo Nishiyama; Masayuki Yamaji; Chiho Kawahara; Masanori Fujii; Takashi Yamamoto; Minoru Horie |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-11-20 |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 33 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-08 Completed Date: 2010-04-21 Revised Date: 2010-06-07 |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
|
Languages: eng Pagination: 118-22 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan. tutamoto@belle.shiga-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aldosterone / blood Angiotensin II / blood* Angiotensin II Type 1 Receptor Blockers / pharmacology* Antihypertensive Agents / pharmacology* Benzimidazoles / pharmacology* Female Humans Hypertension / blood, drug therapy* Hypertrophy, Left Ventricular / prevention & control* Imidazoles / pharmacology* Male Middle Aged Natriuretic Peptide, Brain / blood Peptidyl-Dipeptidase A / genetics Tetrazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Imidazoles; 0/Tetrazoles; 0/olmesartan; 11128-99-7/Angiotensin II; 114471-18-0/Natriuretic Peptide, Brain; 139481-59-7/candesartan; 52-39-1/Aldosterone; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.-/angiotensin converting enzyme 2 |
| Comments/Corrections | |
Comment In:
|
Hypertens Res. 2010 Feb;33(2):105-6
[PMID:
19942930
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and T...
Next Document: Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follo...