| Comparison of a local injection of hyperosmolar glucose solution with salpingostomy for the conservative treatment of tubal pregnancy. | |
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MedLine Citation:
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PMID: 7685719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare a local injection of hyperosmolar glucose and salpingostomy for the laparoscopic treatment of tubal pregnancy in terms of immediate success and postoperative tubal patency. DESIGN: Prospective. PATIENTS, SETTING: Forty women with an unruptured tubal pregnancy were enrolled from among 117 women with ectopic pregnancies (EPs) admitted consecutively to the university clinic. The inclusion criteria were as follows: [1] concentration of beta-hCG in the serum < or = 5,000 IU/L; [2] no living fetus in the EP; and [3] unruptured tubal pregnancy at laparoscopy. INTERVENTIONS: After randomization, 20 of these patients were treated with a local injection of hyperosmolar (50%) glucose solution and 20 women by salpingostomy. Tubal patency was evaluated at relaparoscopy or by hysterosalpingography 6 to 13 months after the primary treatment. RESULTS: The mean decrease in beta-hCG concentration from the preoperative value to the first postoperative day was 37% and 52% in the glucose and salpingostomy groups, respectively, and the mean resolution time was 13 and 12 days, respectively. Human chorionic gonadotropin showed a persistent EP in 4 women (20%) in the glucose group and 2 (10%) in the salpingostomy group. A patent treated tube was found in 9 of 13 women in the glucose group and 9 of 10 in the salpingostomy group at re-examination. During a follow-up of 6 to 20 months 4 women in the glucose group and 4 women in the salpingostomy group had an intrauterine pregnancy. CONCLUSION: A local injection of hyperosmolar glucose is a reasonable method treating tubal pregnancy in selected cases but does not seem to offer any advantage over salpingostomy concerning persistent trophoblastic disease rate. |
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Authors:
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T Laatikainen; L Tuomivaara; K Käär |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fertility and sterility Volume: 60 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-22 Completed Date: 1993-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 80-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Oulu University Central Hospital, Finland. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / blood* Chorionic Gonadotropin, beta Subunit, Human Female Glucose Solution, Hypertonic / administration & dosage* Humans Laparoscopy Peptide Fragments / blood* Pregnancy Pregnancy, Tubal / blood, therapy* Prospective Studies Salpingostomy* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Glucose Solution, Hypertonic; 0/Peptide Fragments |
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