| Comparison of the lipid profile and lipoprotein(a) between sedentary and highly trained subjects. | |
| | |
MedLine Citation:
|
PMID: 16519606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: There is consolidated evidence that physical activity exerts beneficial effects on several chronic conditions and longevity, on the basis of its proposed biological effects, especially on lipid profiles. However, debate continues regarding the intensity of activity required for good health, as vigorous physical activity might overwhelm advantageous changes. In addition, little is known so far on the effect of a vigorous and regular aerobic training regimen on emerging markers of cardiovascular risk, such as lipoprotein(a), total/high-density lipoprotein cholesterol ratio and the atherogenic index of plasma. METHODS: To further investigate this topic, an extensive lipid profile, in accordance with the most recent guidelines issued by the American Heart Association (AHA)/American College of Cardiology (ACC) and the National Cholesterol Education Program (NCEP), was evaluated in 60 healthy male sedentary controls and in a wide population of professional endurance athletes, including 40 male professional cross-country skiers and 102 male professional road cyclists. RESULTS: Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, TC low-density lipoprotein cholesterol (LDL-C) ratio and the atherogenic index of plasma were significantly lower in both categories of professional athletes, whereas the mean HDL-C concentration was significantly higher. The concentration of lipoprotein(a) did not differ significantly between the groups. When compared to current NCEP or AHA/ACC goals, the percentage of patients with undesirable values was statistically different for all parameters tested, apart from lipoprotein(a). According to multiple stepwise logistic regression analysis, lower TC/HDL-C ratio in professional skiers and lower TC/HDL-C ratio and TC in professional cyclists were significantly associated with increased aerobic physical activity. CONCLUSIONS: Results of this case-control study confirm that elevated aerobic energy expenditure might be associated with a highly favorable stabilization of most traditional and emerging cardiovascular risk predictors. Therefore, a substantial increase in aerobic physical activity within the population might be recommended to reverse adverse lipid abnormalities, especially in subjects with a higher cardiovascular risk. |
| | |
Authors:
|
Giuseppe Lippi; Federico Schena; Gian Luca Salvagno; Martina Montagnana; Filippo Ballestrieri; Gian Cesare Guidi |
Related Documents
:
|
8102986 - Total cholesterol, high density lipoprotein cholesterol and steroid hormone changes in ... 3313616 - The effect of exercise on lipid metabolism in men and women. 7997846 - Salt restriction and increased insulin production in hypertensive patients. 10333656 - Positive and negative life changes and ldl cholesterol. 19424216 - Quantitative effects on cardiovascular risk factors and coronary heart disease risk of ... 8774236 - Interactions in indices of vitamin a, zinc and copper status when these nutrients are f... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 44 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-03-07 Completed Date: 2006-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 322-6 Citation Subset: IM |
Affiliation:
|
Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy. ulippi@tin.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiovascular Diseases / pathology, prevention & control Cholesterol, HDL / blood Cholesterol, LDL / blood Exercise / physiology* Humans Lipids / blood* Lipoproteins / blood* Male Physical Fitness / physiology* Regression Analysis Sports / physiology* United States |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: C-reactive protein and neopterin levels in healthy non-obese adults.
Next Document: Clinical outcome estimates based on treatment target limits of laboratory tests: proposal for a plot...